What is the largest vein in the human body that returns deoxygenated blood from the upper half of the body to the right atrium of the heart?

Granzymes are a family of serine proteases that are stored in and secreted from the cytotoxic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

They work in synergy with perforin, a pore-forming toxin, to induce apoptosis in target cells.

Perforin is necessary for the delivery of granzyme B to the target cell cytosol where caspase-dependent and -independent pathways to apoptosis are activated.

Perforins (choice A) are pore-forming toxins that work in synergy with granzymes to induce apoptosis in target cells.

Cytokines (choice B) are signaling molecules that regulate immune responses but do not directly induce apoptosis in target cells.

Interferons (choice D) are a type of cytokine that play a role in immune responses but do not directly induce apoptosis in target cells.

Early identification and management of potential organ donors must take into consideration specific pathophysiologic changes for medical optimization 1.

The VIPPS (ventilation, infusion and pumping, pharmacological treatment, and specificities) strategy is a mnemonic method that brings together key aspects of the restoration of oxygen delivery to tissues during hemodynamic instability plus organ optimization strategies.

Choice A is incorrect because administering antibiotics to prevent infection is not the most important intervention to preserve organ viability.

Choice C is incorrect because providing emotional support to family members, while important, is not an intervention that directly affects organ viability.

Choice D is incorrect because applying eye drops and ointment to prevent corneal drying is not the most important intervention to preserve organ viability.