The nurse is teaching a client with type 1 diabetes mellitus (DM) about the onset, peak, and duration of a new prescription for glargine insulin. If the insulin is administered at 0800, when is the client most likely to experience hypoglycemia?

Choice A reason: Flatulence and nausea are common side effects of azithromycin, which is a macrolide antibiotic that inhibits bacterial protein synthesis. These symptoms are usually mild and transient, and do not require reporting to the health care provider unless they are severe or persistent.

Choice B reason: Urinary frequency is not a relevant symptom of azithromycin, which does not affect urinary function or bladder control. Urinary frequency may be caused by other factors, such as infection, diabetes, or pregnancy.

Choice C reason: Yellow sclera is a serious symptom of azithromycin, which indicates liver damage or jaundice. Azithromycin can cause hepatotoxicity, which is a rare but potentially fatal adverse reaction. Yellow sclera should be reported to the health care provider immediately, as it may require discontinuation of the medication and liver function tests.

Choice D reason: Headache is a common side effect of azithromycin, which is a macrolide antibiotic that inhibits bacterial protein synthesis. This symptom is usually mild and transient, and does not require reporting to the health care provider unless it is severe or persistent.

Choice A reason: Midmorning is not a likely time for experiencing hypoglycemia after administering glargine insulin at 0800, because glargine insulin has a slow onset of action (about 1 hour) and does not have a pronounced peak effect. Glargine insulin is a long-acting insulin that provides a steady level of insulin throughout the day and night.

Choice B reason: No peak occurs is the correct answer for when hypoglycemia is most likely to occur after administering glargine insulin at 0800, because glargine insulin does not have a pronounced peak effect that could cause a sudden drop in blood glucose levels. Glargine insulin is a long-acting insulin that provides a steady level of insulin throughout the day and night.

Choice C reason: Midafternoon is not a likely time for experiencing hypoglycemia after administering glargine insulin at 0800, because glargine insulin has a long duration of action (about 24 hours) and does not have a pronounced peak effect. Glargine insulin is a long-acting insulin that provides a steady level of insulin throughout the day and night.

Choice D reason: Shortly after midnight is not a likely time for experiencing hypoglycemia after administering glargine insulin at 0800, because glargine insulin has a long duration of action (about 24 hours) and does not have a pronounced peak effect. Glargine insulin is a long-acting insulin that provides a steady level of insulin throughout the day and night.