The nurse is reviewing the medication orders for a patient who will be receiving aminoglycoside therapy.
Which other medication or medication class, if ordered, would be a potential interaction concern?
Proton pump inhibitors
Calcium channel blockers
Loop diuretics
Phenytoin
The Correct Answer is C
Choice A rationale:
Proton pump inhibitors (PPIs) are used extensively for the treatment of gastric acid-related disorders, often over the long term, which raises the potential for clinically significant drug interactions in patients receiving concomitant medications.
However, there is no specific mention of a significant interaction between PPIs and aminoglycosides.
Choice B rationale:
Aminoglycoside antibiotics and calcium channel blockers can interact at the neuromuscular junctions. This interaction is of clinical significance because when these agents are given concurrently during the perioperative period they may lead to respiratory depression or prolonged apnea. However, this is not directly related to the therapeutic effect of aminoglycosides, but rather a side effect of their combined use.
Choice C rationale:
The loop-diuretics (ethacrynic acid, furosemide, bumetamide) and aminoglycoside antibiotics (kanamycin, gentamicin, tobramycin, amikacin, etc.) are important drugs frequently used to treat seriously ill patients. Not uncommonly both types of drugs are given to the same patient exposing that patient to the risk of a hearing loss (ototoxicity)5. In addition, the risk of ototoxicity could be enhanced by the concomitant use of loop diuretics and aminoglycoside antibiotics.
Choice D rationale:
Phenytoin is a medication used to treat seizures. It has a complex pharmacokinetic profile and can interact with many other drugs. However, there is no specific mention of a significant interaction between phenytoin and aminoglycosides.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A rationale:
Constipation is not typically associated with hyperthyroidism. In fact, one of the symptoms of hyperthyroidism is increased bowel movement. This is due to the increased metabolic rate caused by the overproduction of hormones from the thyroid gland.
Choice B rationale:
Weight gain is not a common symptom of hyperthyroidism. On the contrary, weight loss is one of the symptoms of this condition. This is because hyperthyroidism speeds up the body’s metabolism, causing increased calorie burning and significant weight loss. Choice C rationale:
Sensitivity to cold is not a symptom of hyperthyroidism. Instead, individuals with hyperthyroidism often have an increased sensitivity to heat. This is due to the increased metabolic rate which can cause excessive sweating and hot flashes.
Choice D rationale:
Frequent mood changes are a common symptom of hyperthyroidism. The overproduction of hormones by the thyroid gland can lead to symptoms such as irritability and restlessness. Additionally, other symptoms such as difficulty sleeping can also contribute to mood changes.
Correct Answer is C
Explanation
Choice A rationale:
This choice is incorrect. While it’s true that antiviral drugs can be effective in treating the flu, they’re most effective when started within 48 hours of symptom onset. Starting treatment after 4 days may not provide the same benefits.
Choice B rationale:
This choice is incorrect. While a blood test can confirm the presence of the flu virus, it’s not typically necessary to diagnose the flu. Diagnosis is usually based on symptoms and the fact that the flu is widespread in the community.
Choice C rationale:
This choice is correct. Antiviral drugs are most effective when started within 2 days of symptom onset. After this time, the benefits of these drugs decrease. Therefore, starting treatment 4 days after symptoms begin may not significantly reduce the duration or severity of symptoms.
Choice D rationale:
This choice is incorrect. While it’s true that getting a flu vaccine is important, it’s not the best response in this situation. The flu vaccine won’t treat current illness. It’s designed to prevent future infections. In this case, the individual is already sick, so a booster vaccination wouldn’t be the most effective course of action.
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