The nurse is reviewing the medication orders for a patient who will be receiving aminoglycoside therapy.
Which other medication or medication class, if ordered, would be a potential interaction concern?

Proton pump inhibitors

Calcium channel blockers

Loop diuretics

Phenytoin

Answer and Explanation

The Correct Answer is C

Choice A rationale:

Proton pump inhibitors (PPIs) are used extensively for the treatment of gastric acid-related disorders, often over the long term, which raises the potential for clinically significant drug interactions in patients receiving concomitant medications.

However, there is no specific mention of a significant interaction between PPIs and aminoglycosides.

Choice B rationale:

Aminoglycoside antibiotics and calcium channel blockers can interact at the neuromuscular junctions. This interaction is of clinical significance because when these agents are given concurrently during the perioperative period they may lead to respiratory depression or prolonged apnea. However, this is not directly related to the therapeutic effect of aminoglycosides, but rather a side effect of their combined use.

Choice C rationale:

The loop-diuretics (ethacrynic acid, furosemide, bumetamide) and aminoglycoside antibiotics (kanamycin, gentamicin, tobramycin, amikacin, etc.) are important drugs frequently used to treat seriously ill patients. Not uncommonly both types of drugs are given to the same patient exposing that patient to the risk of a hearing loss (ototoxicity)5. In addition, the risk of ototoxicity could be enhanced by the concomitant use of loop diuretics and aminoglycoside antibiotics.

Choice D rationale:

Phenytoin is a medication used to treat seizures. It has a complex pharmacokinetic profile and can interact with many other drugs. However, there is no specific mention of a significant interaction between phenytoin and aminoglycosides.

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Correct Answer is D

Explanation

Choice A rationale:

Liothyronine (Cytomel) is a type of thyroid hormone used to treat an underactive thyroid (hypothyroidism). It replaces or provides more thyroid hormone, which is normally produced by the thyroid gland. However, it is not typically used to treat hyperthyroidism.

Choice B rationale:

Liotrix (Thyrolar) is a combination of two thyroid hormones, levothyroxine (T4) and liothyronine (T3), used to treat hypothyroidism, and to prevent and treat goiter. Similar to Liothyronine, it is not typically used to treat hyperthyroidism. Choice C rationale:

Levothyroxine (Synthroid) is used to treat an underactive thyroid (hypothyroidism). It replaces or provides more thyroid hormone, which is normally produced by the thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation/medications or removed by surgery. Having enough thyroid hormone helps maintain normal mental and physical activity. In children, having enough thyroid hormone helps them grow and learn normally.

Choice D rationale:

Propylthiouracil (Propacil) is an antithyroid agent used in the treatment of hyperthyroidism. It works by decreasing the amount of thyroid hormone produced by the thyroid gland. This helps to prevent the excessive heat, rapid heart rate, and nervousness caused by too much thyroid hormone in the body.

A. The client’s family will also need to take medications to prevent infection. B. A typical course of treatment involves 6 to 9 months of consistent medication use. C. Medications will need to be taken for the rest of the client’s life, even if the client feels better. D. Medications will need to be taken until the Mantoux test is negative.

Correct Answer is B

Explanation

Choice A rationale:

While it’s important for the client’s family to be aware of the disease and take precautions, they do not necessarily need to take medications to prevent infection. Tuberculosis (TB) is a contagious disease, but it typically requires close and prolonged contact to spread. Family members should be tested for TB, and if they test positive, then treatment would be necessary.

Choice B rationale:

This is the correct answer. A typical course of treatment for TB involves 6 to 9 months of consistent medication use. This is because TB bacteria die very slowly, and medications need to be taken for several months to ensure that all the bacteria are killed. If treatment is stopped too soon, some bacteria may survive and become resistant to the drugs.

Choice C rationale:

It’s not accurate to say that medications will need to be taken for the rest of the client’s life. While TB treatment is lengthy, it does not continue indefinitely. Once the full course of treatment is completed and the disease is cured, further medication is not typically necessary.

Choice D rationale:

The Mantoux test, also known as the tuberculin skin test, is used to determine whether a person has TB infection. However, the test can remain positive for a long time, even after successful treatment. Therefore, medications should not be taken until the Mantoux test is negative. Instead, the duration of treatment is determined by the healthcare provider based on various factors, including the patient’s response to the medication.

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The nurse is reviewing the medication orders for a patient who will be receiving aminoglycoside therapy. Which other medication or medication class, if ordered, would be a potential interaction concern?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

Which of the following medications is typically prescribed for the treatment of hyperthyroidism?

Correct Answer is D

Explanation

A nurse is instructing a client newly diagnosed with pulmonary tuberculosis (TB) about the use of antitubercular medications. What information should the nurse include in the teaching?

Correct Answer is B

Explanation

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The nurse is reviewing the medication orders for a patient who will be receiving aminoglycoside therapy.
Which other medication or medication class, if ordered, would be a potential interaction concern?