The nurse is reviewing the medication orders for a patient who will be receiving aminoglycoside therapy.
Which other medication or medication class, if ordered, would be a potential interaction concern?

Proton pump inhibitors

Calcium channel blockers

Loop diuretics

Phenytoin

Answer and Explanation

The Correct Answer is C

Choice A rationale:

Proton pump inhibitors (PPIs) are used extensively for the treatment of gastric acid-related disorders, often over the long term, which raises the potential for clinically significant drug interactions in patients receiving concomitant medications.

However, there is no specific mention of a significant interaction between PPIs and aminoglycosides.

Choice B rationale:

Aminoglycoside antibiotics and calcium channel blockers can interact at the neuromuscular junctions. This interaction is of clinical significance because when these agents are given concurrently during the perioperative period they may lead to respiratory depression or prolonged apnea. However, this is not directly related to the therapeutic effect of aminoglycosides, but rather a side effect of their combined use.

Choice C rationale:

The loop-diuretics (ethacrynic acid, furosemide, bumetamide) and aminoglycoside antibiotics (kanamycin, gentamicin, tobramycin, amikacin, etc.) are important drugs frequently used to treat seriously ill patients. Not uncommonly both types of drugs are given to the same patient exposing that patient to the risk of a hearing loss (ototoxicity)5. In addition, the risk of ototoxicity could be enhanced by the concomitant use of loop diuretics and aminoglycoside antibiotics.

Choice D rationale:

Phenytoin is a medication used to treat seizures. It has a complex pharmacokinetic profile and can interact with many other drugs. However, there is no specific mention of a significant interaction between phenytoin and aminoglycosides.

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Correct Answer is C

Explanation

Choice A rationale:

Blood glucose levels are not typically affected by rifampin and pyrazinamide. These medications are primarily used to treat tuberculosis and do not have a direct impact on blood sugar levels.

Choice B rationale:

Thyroid function studies are not usually required when a patient is on rifampin and pyrazinamide. These medications do not typically affect the thyroid gland or its function.

Choice C rationale:

Liver function tests are crucial when a patient is on rifampin and pyrazinamide. Both of these medications can cause liver problems, including hepatitis. Therefore, regular monitoring of liver function is necessary to detect any potential damage early and adjust the treatment plan accordingly.

Choice D rationale:

Gallbladder studies are not typically required for patients on rifampin and pyrazinamide. These medications do not have a known direct impact on the gallbladder.

A. Acyclovir B. Ribavirin C. C. Foscarnet D. Zidovudine

Correct Answer is D

Explanation

Choice A rationale:

Acyclovir is an antiviral medication used to treat infections caused by certain types of viruses. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. However, it is not typically used as an anti-HIV drug.

Choice B rationale:

Ribavirin is an antiviral medication used to treat hepatitis C and certain other viral infections. While it has broad-spectrum antiviral activity, it is not specifically used to prevent mother-to-child transmission of HIV.

Choice C rationale:

Foscarnet is an antiviral medication used to treat or prevent cytomegalovirus (CMV) retinitis in individuals with AIDS. It is also used to treat cold sores and genital herpes. However, it is not the first-line choice for preventing mother-to-child transmission of HIV.

Choice D rationale:

Zidovudine, also known as AZT, is an antiretroviral medication used to prevent and treat HIV/AIDS. It is generally safe for use during pregnancy and is commonly used to prevent mother-to-child transmission of HIV12. It works by inhibiting the reverse transcriptase enzyme, thereby blocking viral replication. The use of Zidovudine and other antiretroviral drugs in pregnant women with HIV has significantly reduced the rate of mother-to-child transmission of the virus.

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The nurse is reviewing the medication orders for a patient who will be receiving aminoglycoside therapy. Which other medication or medication class, if ordered, would be a potential interaction concern?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is caring for a client who has tuberculosis and new prescriptions for rifampin and pyrazinamide. Which of the following laboratory tests should the nurse instruct the client will be required while on this medication regimen?

Correct Answer is C

Explanation

The nurse is providing counseling to a woman who is HIV positive and has just discovered that she is pregnant. Which anti-HIV drug is given to HIV-infected pregnant women to prevent transmission of the virus to the infant?

Correct Answer is D

Explanation

When a patient is undergoing aminoglycoside therapy, which indicators should the nurse monitor for potential toxicity?

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A nurse is reinforcing teaching with a client who has type 2 diabetes mellitus. The nurse determines that teaching has been effective when the client identifies which of the following manifestations of hypoglycemia? (Select all that apply.)

A nurse is caring for a client who is to receive liquid medications via a gastrostomy tube. The client is prescribed phenytoin 250 mg. The amount available is phenytoin oral solution 25 mg/5 mL. How many mL should the nurse administer per dose?

Phenytoin has a narrow therapeutic index. The nurse recognizes that this characteristic indicates which of these?

When given an intravenous medication, the patient asks the nurse, “I usually take pills. Why does this medication have to be given in the arm?” What is the nurse’s best response?

The nurse is reviewing the medication orders for a patient who will be receiving aminoglycoside therapy.
Which other medication or medication class, if ordered, would be a potential interaction concern?