Hyperglycemic Hyperosmolar Nonketoic (HHNK) is an acute complication of:

Choice A reason: Reversible deviant cells do not accurately describe neoplasia. Neoplasia involves the uncontrolled and irreversible growth of abnormal cells. While some deviant cell changes can be reversible, neoplasia specifically refers to irreversible changes that lead to tumor formation.

Choice B reason: Neoplasia does not adhere to the genetic controls placed on cellular proliferation and differentiation. In fact, the hallmark of neoplasia is the loss of these regulatory mechanisms, leading to uncontrolled cell growth and differentiation.

Choice C reason: Neoplasia indeed alters cellular proliferation and differentiation. This alteration is due to genetic mutations and other changes that lead to the loss of normal growth control. The result is the formation of tumors, which can be benign or malignant.

Choice D reason: Controlled and regulated cells do not describe neoplasia. Neoplastic cells grow and proliferate without the normal regulatory signals that control cell growth and differentiation. This uncontrolled growth is what characterizes neoplasia.

Choice A reason: While white blood cells (WBC) are essential for fighting infections, increased WBCs in the blood is not the reason why a minor injury can cause major complications in individuals with diabetes. In fact, diabetes can impair the function of WBCs, making it harder to fight infections.

Choice B reason: Edema, or swelling, can occur in individuals with diabetes, especially in the lower extremities. However, it is not the primary reason why minor injuries can lead to severe complications. Edema can contribute to discomfort and further complications, but it is not the root cause.

Choice C reason: Increased blood flow and oxygen delivery to tissues would generally be beneficial for healing. However, individuals with diabetes often have impaired blood flow, not increased blood flow. This impairment can hinder the healing process and lead to complications.

Choice D reason: The major reason why a minor injury can cause significant complications in individuals with diabetes is due to decreased blood flow to the tissues. Diabetes can cause damage to blood vessels and nerves (peripheral neuropathy), leading to poor circulation and a reduced ability to sense injuries. This decreased blood flow can prevent adequate delivery of oxygen and nutrients to the tissues, leading to slow healing, increased risk of infection, and in severe cases, gangrene (tissue death). Without proper blood flow, even minor injuries can become serious and may require medical intervention, including possible amputation to prevent the spread of infection.