Glyburide works by which of the following mechanisms?
Stimulating glucose uptake in the skeletal muscles.
Increasing the cells' sensitivity to insulin.
Stimulating the release of insulin from the pancreas.
Inhibiting the breakdown of carbohydrates in the intestines.
The Correct Answer is C
Choice A rationale
Glyburide does not stimulate glucose uptake directly in skeletal muscles. Instead, it acts on pancreatic beta cells, affecting insulin release. Enhancing muscular glucose uptake occurs through insulin’s action downstream.
Choice B rationale
Glyburide does not primarily increase insulin sensitivity. Agents like metformin work to sensitize cells to insulin, but Glyburide functions by stimulating endogenous insulin release.
Choice C rationale
Glyburide stimulates insulin release from pancreatic beta cells by closing ATP-sensitive potassium channels, leading to calcium influx and insulin secretion. This increases circulating insulin, aiding glucose uptake and reducing blood glucose levels.
Choice D rationale
Glyburide does not inhibit carbohydrate breakdown in the intestines. Medications like alpha-glucosidase inhibitors target intestinal enzymes to slow carbohydrate digestion, unlike Glyburide’s pancreatic action.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Choice A rationale
Administering 1 mg of glucagon intramuscularly is unnecessary for a patient who is awake, alert, and able to swallow. Glucagon is reserved for patients who are unconscious and unable to swallow effectively to prevent choking.
Choice B rationale
Administering 25 g of dextrose IVP is unnecessary in this case because the patient is alert and able to swallow. Oral intake of carbohydrates is the preferred and safer intervention for mild hypoglycemia like 69 mg/dL.
Choice C rationale
Holding the insulin and encouraging the patient to eat provides glucose through dietary means, which is appropriate in a patient who is awake, alert, and hungry. A level of 69 mg/dL, though below normal, can be managed with oral glucose intake safely.
Choice D rationale
Calling the MD is not the immediate priority in managing mild hypoglycemia. Intervening directly to correct the glucose level with oral intake is more appropriate and effective in this situation.
Correct Answer is D
Explanation
Choice A rationale
Lispro (Humalog) is a rapid-acting insulin used for mealtime glucose control. It has an onset of 15 minutes and peaks within 30 minutes to 1 hour, making it unsuitable for basal dosing.
Choice B rationale
Aspart (NovoLog), another rapid-acting insulin, is similar to lispro in its onset and peak times. It is also used for mealtime glucose control, not basal glucose regulation.
Choice C rationale
Regular insulin (Humulin R) is a short-acting insulin with an onset of 30 minutes to 1 hour and a peak of 2 to 4 hours. It cannot provide the steady basal glucose control required for 24-hour coverage.
Choice D rationale
Glargine (Lantus) is a long-acting insulin that provides consistent basal glucose control with no pronounced peak. It is designed for once-daily dosing to maintain stable glucose levels over 24 hours, meeting the requirements for basal dosing. .
Whether you are a student looking to ace your exams or a practicing nurse seeking to enhance your expertise , our nursing education contents will empower you with the confidence and competence to make a difference in the lives of patients and become a respected leader in the healthcare field.
Visit Naxlex, invest in your future and unlock endless possibilities with our unparalleled nursing education contents today
Report Wrong Answer on the Current Question
Do you disagree with the answer? If yes, what is your expected answer? Explain.
Kindly be descriptive with the issue you are facing.