A nurse is reinforcing teaching with the parent of a child who has otitis media and a new prescription for amoxicillin oral suspension. Which of the following information should the nurse include?

Choice A rationale:
Urticaria, commonly known as hives, is a skin rash characterized by raised, red, and itchy welts that can vary in size and shape. It is a classic manifestation of an allergic reaction. Allergic reactions can occur in response to medications like clindamycin. Urticaria is a result of histamine release and can range from mild to severe, with itching being a prominent symptom. The appearance of urticaria in a child taking clindamycin suggests a potential allergic reaction to the medication.
Choice B rationale:
Conjunctivitis, or pink eye, is inflammation of the conjunctiva, the clear membrane that covers the white part of the eye and lines the inner surface of the eyelids. While conjunctivitis can be associated with allergies, it is not a typical sign of an allergic reaction to clindamycin. Conjunctivitis is more commonly associated with eye irritation, redness, and discharge.
Choice C rationale:
A temperature of 38°C (100.4°F) alone is not a definitive sign of an allergic reaction to medication. Fever can be caused by a variety of factors, including infections, inflammatory processes, and other non-allergic reactions. While fever can be a symptom of an allergic reaction in some cases, it is not as specific as urticaria in indicating an allergic response.
Choice D rationale:
Cool extremities are not a classic sign of an allergic reaction to medication. Allergic reactions typically involve skin manifestations like hives, itching, and redness. Cool extremities might suggest poor peripheral circulation or decreased blood flow to the extremities, but they are not directly indicative of an allergic reaction to clindamycin.

Choice A rationale:
Edema. Edema, the accumulation of fluid in the tissues, is not the primary indicator of compartment syndrome. While edema can occur due to various reasons, it's not specific to compartment syndrome. Compartment syndrome primarily involves increased pressure within a closed space (muscle compartment), which can compromise blood circulation and nerve function.
Choice B rationale:
Mottling. Mottling refers to a patchy, bluish discoloration of the skin that occurs due to poor blood circulation and is often seen in critically ill patients. While it might indicate circulatory issues, it's not a direct sign of compartment syndrome. Compartment syndrome is more closely associated with symptoms such as severe pain, numbness, and decreased or absent pulses.
Choice C rationale:
Urticaria. Urticaria, also known as hives, is a skin rash characterized by raised, itchy, and red or white welts. It is typically caused by an allergic reaction or other factors such as medications. Urticaria is unrelated to compartment syndrome, which involves the compression of nerves and blood vessels within a closed anatomical compartment, leading to ischemia and potential tissue damage.
Choice D rationale:
Pulselessness. Pulselessness is a critical sign that the nurse should monitor when conducting a circulatory check for compartment syndrome. Compartment syndrome occurs when there is increased pressure within a confined space (muscle compartment), leading to compromised blood flow and oxygen delivery to the tissues. The lack of a palpable pulse in the affected area suggests that blood flow is severely compromised. This is a late sign of compartment syndrome and requires immediate intervention to prevent tissue necrosis and long-term complications.