A nurse is preparing to administer an aminoglycoside to a client.
The nurse would be alert for the development of which of the following toxicities?

Nephrotoxicity.

Cardiotoxicity.

Hepatotoxicity.

Cytotoxicity.

Answer and Explanation

The Correct Answer is A

Choice A rationale:

Aminoglycosides are known to have nephrotoxic effects. Nephrotoxicity refers to kidney toxicity, and aminoglycosides can cause damage to the renal tubules, leading to impaired kidney function. The nurse should be alert to this potential toxicity when administering these drugs, as it can result in kidney dysfunction, altered serum creatinine levels, and electrolyte imbalances.

Choice B rationale:

Cardiotoxicity is not typically associated with aminoglycosides. These antibiotics primarily affect the kidneys and the inner ear. There is no direct relationship between aminoglycosides and cardiac toxicity.

Choice C rationale:

Hepatotoxicity refers to liver toxicity and is not a common side effect of aminoglycosides. Aminoglycosides are primarily metabolized in the kidneys and are excreted through urine, making kidney toxicity a more significant concern.

Choice D rationale:

Cytotoxicity is a broad term that refers to the toxicity of cells. Aminoglycosides do not typically cause generalized cytotoxic effects in the body. Their primary toxicities are related to specific organ systems, such as the kidneys and the inner ear.

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Correct Answer is C

Explanation

Choice A rationale:

The goal of having the client state adverse reactions to report is important, but it is not the primary goal of antitubercular therapy. The main objective is to ensure that the client and their family understand the drug regimen to promote adherence and successful treatment. This is crucial in preventing drug-resistant tuberculosis and achieving the desired outcome.

Choice B rationale:

Maintaining adequate nutritional status is essential for overall health, but it is not the primary goal of antitubercular therapy. While good nutrition can support the immune system, the central goal should be related to medication adherence and preventing the spread of tuberculosis.

Choice D rationale:

Client managing the therapeutic regimen effectively is an important aspect of tuberculosis treatment, but this choice lacks the emphasis on educating the client and their family about the drug regimen, which is a fundamental component of successful therapy.

Choice E rationale:

The negative sputum culture is an indicator of treatment success, but it's more of an outcome measure than a goal for the client. The primary goal should focus on education and adherence to the drug regimen.

A. Protease inhibitors. B. Reverse transcriptase inhibitors. C. Nonnucleoside reverse transcriptase inhibitors. D. Integrase inhibitors.

Correct Answer is A

Explanation

Choice A rationale:

Protease inhibitors are a category of antiretroviral drugs used in the treatment of HIV. They work by affecting an enzyme called protease, which is necessary for the maturation of new viral particles. By inhibiting protease, these drugs prevent the formation of mature, infectious HIV particles.

Choice B rationale:

Reverse transcriptase inhibitors, including both nucleoside and non-nucleoside variants, target the enzyme reverse transcriptase. This enzyme is involved in the conversion of HIV RNA into DNA, an essential step in the viral life cycle. However, it's not about preventing the maturation of new viral particles, as mentioned in the question.

Choice C rationale:

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) also inhibit the reverse transcriptase enzyme, but they do so differently than protease inhibitors. While they are vital in HIV treatment, they do not specifically target the maturation of viral particles.

Choice D rationale:

Integrase inhibitors target the enzyme integrase, which is involved in the integration of viral DNA into the host cell's DNA. This step is crucial in the HIV life cycle, but it's not related to the maturation of new viral particles.

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A nurse is preparing to administer an aminoglycoside to a client.The nurse would be alert for the development of which of the following toxicities?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

When developing the plan of care for a client receiving antitubercular therapy, the nurse would identify which of the following as a goal? Alert to the development of which of the following?

Correct Answer is C

Explanation

A nursing instructor is describing the different categories of antiretroviral agents used in treatment for HIV infection.The instructor determines that the teaching was successful when the students identify which category as affecting an enzyme so that new viral particles cannot mature?

Correct Answer is A

Explanation

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A nurse is preparing to administer an aminoglycoside to a client.
The nurse would be alert for the development of which of the following toxicities?