A nurse is caring for a client with a new order for acetaminophen.
What of the following options is a therapeutic use of this medication?

Choice A rationale

Furosemide is a loop diuretic that acts on the ascending limb of the loop of Henle, not the distal tubule.

Choice B rationale

Spironolactone is a potassium-sparing diuretic that works on the collecting ducts and late distal tubules, not the distal tubule.

Choice C rationale

Mannitol is an osmotic diuretic that acts on the proximal tubule and the descending limb of the loop of Henle, not the distal tubule.

Choice D rationale

Hydrochlorothiazide is a thiazide diuretic that works on the distal convoluted tubule, making it the correct answer.

Choice A rationale

Celecoxib does not inhibit the histamine response. Histamine is involved in allergic reactions, and celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that targets specific enzymes involved in inflammation.

Choice B rationale

Celecoxib specifically inhibits COX-2, an enzyme involved in the inflammation pathway. This selective inhibition helps reduce inflammation and pain without significantly affecting COX-1, which is protective for the stomach lining.

Choice C rationale

COX-1 is not the primary target of celecoxib. Inhibition of COX-1 can lead to gastrointestinal side effects, which celecoxib aims to minimize by selectively inhibiting COX-2 instead.

Choice D rationale

Celecoxib does not inhibit beta receptors. Beta receptors are involved in cardiovascular responses, and beta blockers are used for conditions like hypertension, not inflammation.