A group of nursing students are reviewing information about antiretroviral therapy.
The students demonstrate understanding of the information when they identify which conditions as requiring cautious use of this class of drugs?

Choice A rationale:

Impaired hepatic function requires cautious use of antiretroviral therapy. Many antiretroviral drugs are metabolized in the liver, and impaired hepatic function can affect drug metabolism and lead to potential drug interactions and toxicity. Adjustments in antiretroviral therapy may be needed in individuals with liver impairment.

Choice B rationale:

Impaired renal function also requires cautious use of antiretroviral therapy. Some antiretroviral drugs are eliminated by the kidneys, and impaired renal function can affect drug clearance. Dosing adjustments and drug selection may be necessary in individuals with renal impairment to prevent drug accumulation and toxicity.

Choice C rationale:

Hypertension is not a specific condition that requires cautious use of antiretroviral therapy. While some antiretroviral drugs can have side effects related to blood pressure, such as protease inhibitors, hypertension itself is not a contraindication for antiretroviral therapy.

Choice D rationale:

COPD (Chronic Obstructive Pulmonary Disease) is not a specific condition that requires cautious use of antiretroviral therapy. Antiretroviral therapy is primarily used in the treatment of HIV, and COPD is a lung condition unrelated to HIV. The two conditions do not directly interact, and COPD is not a contraindication for antiretroviral therapy. .