A client has been receiving treatment with antineoplastic drugs that depress the bone marrow.
Which preadministration assessment would be most important for the nurse to complete with respect to this effect?

Choice A rationale:

Protease inhibitors are a category of antiretroviral drugs used in the treatment of HIV. They work by affecting an enzyme called protease, which is necessary for the maturation of new viral particles. By inhibiting protease, these drugs prevent the formation of mature, infectious HIV particles.

Choice B rationale:

Reverse transcriptase inhibitors, including both nucleoside and non-nucleoside variants, target the enzyme reverse transcriptase. This enzyme is involved in the conversion of HIV RNA into DNA, an essential step in the viral life cycle. However, it's not about preventing the maturation of new viral particles, as mentioned in the question.

Choice C rationale:

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) also inhibit the reverse transcriptase enzyme, but they do so differently than protease inhibitors. While they are vital in HIV treatment, they do not specifically target the maturation of viral particles.

Choice D rationale:

Integrase inhibitors target the enzyme integrase, which is involved in the integration of viral DNA into the host cell's DNA. This step is crucial in the HIV life cycle, but it's not related to the maturation of new viral particles.

Choice A rationale:

Wear protective clothing and sunscreen when outside. Rationale: Sulfonamide antibiotics, a type of medication mentioned in the question, can increase the skin's sensitivity to sunlight, leading to photosensitivity reactions. To reduce the effects of photosensitivity, the client should be instructed to wear protective clothing that covers the skin and to apply sunscreen with a high sun protection factor (SPF) when going outdoors. This helps shield the skin from harmful UV rays, reducing the risk of sunburn and other adverse reactions.

Choice B rationale:

Increase fluid intake. Rationale: Increasing fluid intake is a general recommendation for clients taking sulfonamide antibiotics to minimize the risk of crystalluria, a side effect that can result from inadequate hydration. Crystalluria is the formation of crystals in the urine and can lead to kidney stones. While staying hydrated is essential, it is not specifically related to reducing photosensitivity, which is the focus of this question.

Choice C rationale:

Avoid lights while indoors. Rationale: Avoiding lights while indoors is not a standard precaution to reduce the effects of photosensitivity caused by sulfonamide antibiotics. Photosensitivity primarily refers to the skin's heightened sensitivity to sunlight. Being indoors under regular lighting conditions should not significantly impact photosensitivity. The key precautions are related to outdoor sun exposure.

Choice D rationale:

Wear protective footwear. Rationale: Wearing protective footwear is not a standard precaution to reduce photosensitivity effects caused by sulfonamide antibiotics. Photosensitivity primarily affects the skin, not the feet. While protective footwear may be recommended in specific situations, such as in a construction or industrial setting, it is not directly related to reducing the risk of photosensitivity reactions.