A nurse is preparing to administer antiviral therapy.
The nurse integrates knowledge of this therapy, administering the drugs cautiously to clients with which of the following?

Choice A rationale:

Antiviral drugs are metabolized in the liver, and hepatic impairment can affect the metabolism and elimination of these drugs. Therefore, the nurse should administer antiviral therapy cautiously to clients with hepatic impairment to prevent potential drug toxicity. Hepatic impairment can alter the pharmacokinetics of antiviral drugs, leading to increased drug levels in the bloodstream.

Choice B rationale:

Renal impairment is not typically a contraindication for antiviral therapy. While some medications may require dose adjustments in patients with renal impairment, it is not a general concern for antiviral drugs. The primary organ responsible for the metabolism of antiviral drugs is the liver.

Choice C rationale:

Diabetes and hypertension are chronic medical conditions that are not directly related to the administration of antiviral therapy. These conditions do not significantly impact the pharmacokinetics or pharmacodynamics of antiviral drugs. Therefore, they are not primary factors to consider when administering antiviral therapy.

Choice D rationale:

Hypertension, like diabetes, is not directly related to the administration of antiviral therapy. Antiviral drugs primarily interact with the liver's metabolic pathways, and hypertension does not have a significant impact on drug metabolism.