Clinical Manifestations of Hemophilia
- The clinical manifestations of hemophilia vary depending on the type, severity, and location of bleeding.
- The most common symptom is hemarthrosis, which is bleeding into joints, causing pain, swelling, stiffness, and reduced range of motion. Repeated joint bleeds can lead to chronic synovitis, cartilage damage, and joint deformity.
- Other symptoms include bleeding into muscles, soft tissues, mucous membranes, gastrointestinal tract, urinary tract, central nervous system, and internal organs. These can cause hematoma, bruising, hematuria, melena, hematemesis, headache, seizures, paralysis, shock, and death.
- Bleeding can be triggered by trauma, surgery, dental procedures, injections, menstruation, or spontaneous without any apparent cause.
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