Which term is best for the nurse to use to describe replacement of ciliated columnar cells to stratified squamous epithelial cells in the bronchi that were diagnosed in a client?

Hyperplasia

Metaplasia

Neoplasia

Dysplasia

Answer and Explanation

The Correct Answer is B

Choice A reason: Hyperplasia is not the best term because it is a condition where the number of cells in a tissue or organ increases, which can be caused by various factors, such as hormones, inflammation, or stress. Hyperplasia does not involve the change of cell type, but the increase of cell number.

Choice B reason: Metaplasia is the best term because it is a condition where the type of cells in a tissue or organ changes, usually in response to chronic irritation or injury. Metaplasia involves the replacement of one type of cell with another type of cell that is more resistant to the harmful stimulus, but less specialized in function. Metaplasia can occur in the bronchi, which are the airways that branch from the trachea to the lungs, and are normally lined with ciliated columnar cells, which are cells that have hair-like projections that help to move mucus and foreign particles out of the respiratory tract. Metaplasia can replace the ciliated columnar cells with stratified squamous epithelial cells, which are cells that have multiple layers and a flat shape, and are more durable, but less effective in clearing the airways.

Choice C reason: Neoplasia is not the best term because it is a condition where the growth of cells in a tissue or organ is abnormal and uncontrolled, which can result in the formation of tumors, which are masses of abnormal cells that can be benign or malignant. Neoplasia does not involve the change of cell type, but the abnormal proliferation of cells.

Choice D reason: Dysplasia is not the best term because it is a condition where the shape, size, and organization of cells in a tissue or organ are abnormal, which can be caused by various factors, such as chronic inflammation, infection, or precancerous changes. Dysplasia does not involve the change of cell type, but the alteration of cell morphology and arrangement.

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Correct Answer is B

Explanation

Choice A reason: Prostaglandins are inflammatory mediators that are derived from arachidonic acid. They are involved in both the early and late phases of type 1 hypersensitivity response, but they do not cause immediate bronchoconstriction and vasodilation. They mainly cause pain, fever, and inflammation.

Choice B reason: Histamine is an inflammatory mediator that is stored in mast cells and basophils. It is released during the early phase of type 1 hypersensitivity response, which occurs within minutes of exposure to an allergen. It causes immediate bronchoconstriction and vasodilation, as well as increased vascular permeability, mucus secretion, and itching.

Choice C reason: Leukotrienes are inflammatory mediators that are derived from arachidonic acid. They are involved in the late phase of type 1 hypersensitivity response, which occurs several hours after exposure to an allergen. They cause sustained bronchoconstriction and inflammation, as well as increased mucus production and airway edema.

Choice D reason: Bradykinin is an inflammatory mediator that is formed from plasma proteins. It is not directly involved in type 1 hypersensitivity response, but it may be activated by the complement system, which is part of the innate immune system. It causes vasodilation, increased vascular permeability, and pain.

A. Initiates the fibrinolytic process in the arteries B. Decreases highly sensitive C-reactive protein (hsCRP) levels C. Damages the endothelium of the arteries D. Causes diffuse arterial vasoconstriction

Correct Answer is C

Explanation

Choice A reason: Initiates the fibrinolytic process in the arteries is not a role of inflammation in the development of atherosclerosis, but a protective mechanism against it. Fibrinolysis is the breakdown of blood clots by enzymes such as plasmin. It prevents the formation of thrombi that can occlude the arteries and cause ischemia.

Choice B reason: Decreases highly sensitive C-reactive protein (hsCRP) levels is not a role of inflammation in the development of atherosclerosis, but an indicator of it. hsCRP is a marker of systemic inflammation that is produced by the liver in response to cytokines. It is elevated in patients with atherosclerosis and correlates with the risk of cardiovascular events.

Choice C reason: Damages the endothelium of the arteries is the main role of inflammation in the development of atherosclerosis. Endothelial injury exposes the subendothelial layer to the blood, which triggers the adhesion of monocytes and platelets. Monocytes differentiate into macrophages and engulf oxidized low-density lipoproteins (LDL), forming foam cells. Foam cells accumulate in the intima and form fatty streaks, which are the earliest lesions of atherosclerosis.

Choice D reason: Causes diffuse arterial vasoconstriction is not a role of inflammation in the development of atherosclerosis, but a consequence of it. Atherosclerosis narrows the lumen of the arteries and reduces the blood flow to the tissues. This causes ischemia, which stimulates the release of vasoconstrictors such as angiotensin II and endothelin. Vasoconstriction further worsens the ischemia and increases the blood pressure.

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Which term is best for the nurse to use to describe replacement of ciliated columnar cells to stratified squamous epithelial cells in the bronchi that were diagnosed in a client?

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Naxlex Comprehensive Predictor Exams

Which term describes the inflammatory mediator released during the early phase of type 1 hypersensitivity response causing immediate bronchoconstriction and vasodilation?

Correct Answer is B

Explanation

Which explanation does the nurse know best describes the role of inflammation in the development of atherosclerosis?

Correct Answer is C

Explanation

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