Which statement made by the nurse explains the rationale for the use of donepezil for clients diagnosed with Alzheimer's dementia?
Donepezil increases the availability of acetylcholine at cholinergic synapses.
Donepezil decreases acetylcholine in the periphery to increase movement.
Donepezil delays transmission of acetylcholine at the neuronal junction.
Donepezil works to bind the dopamine at neuron receptor sites to increase ability.
The Correct Answer is A
Donepezil is a medication used to treat Alzheimer's dementia. Its main mechanism of action is the inhibition of the acetylcholinesterase enzyme in the brain ¹. This increases the availability of acetylcholine at cholinergic synapses ⁵, which can improve cognition and function in clients with Alzheimer's dementia ¹.
Option B is incorrect because donepezil does not decrease acetylcholine in the periphery to increase movement.
Option C is incorrect because donepezil does not delay the transmission of acetylcholine at the neuronal junction.
Option D is incorrect because donepezil does not bind dopamine at neuron receptor sites to increase ability.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
The client's symptoms of high fever, unstable blood pressure, increased confusion, and rigidity are consistent with neuroleptic malignant syndrome (NMS) ⁴. NMS is a rare but life-threatening reaction that can occur in response to neuroleptic or antipsychotic medication ⁴. In this case, the client was taking olanzapine and was recently prescribed chlorpromazine, both of which are antipsychotic medications that can cause NMS ⁴.
Option A is incorrect because accelerated dementia would not cause the sudden onset of these symptoms.
Option B is incorrect because an infection would not explain the sudden onset of these symptoms after starting a new medication.
Option C is incorrect because aspiration would not cause rigidity or unstable blood pressure.
Correct Answer is A
Explanation
Reduced hepatic blood flow can decrease the metabolism and excretion of many drugs, requiring that doses of some drugs be decreased ². This can increase the risk of medication toxicity in older adults.
Option B is not correct because reduced body fat is not a physiological change associated with aging.
Option C is not correct because the glomerular filtration rate decreases with age ².
Option D is not correct because gastric motility decreases with age ².
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