Which statement is correct about patient tolerance to medications?
The patient will continually require higher doses of the drug for the same effect to be achieved.
Tolerance occurs when the liver or kidneys are no longer able to metabolize the drug.
The patient will require a stable dose of the medication until the drug is discontinued.
Tolerance only develops when the patients do not take the medication as it is prescribed.
The Correct Answer is A
Choice A reason: Tolerance reflects receptor desensitization or enzyme induction; higher doses compensate for reduced drug efficacy, a common pharmacological adaptation.
Choice B reason: Organ failure affects metabolism, not tolerance; tolerance is a cellular response, not solely a failure of liver or kidney drug clearance mechanisms.
Choice C reason: Stable dosing contradicts tolerance; if tolerance develops, efficacy drops, necessitating dose increases, not maintenance, to achieve therapeutic levels.
Choice D reason: Non-adherence may alter response, but tolerance occurs with consistent use; it’s a physiological adaptation, not a result of misuse or skipping doses.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A reason: A 12-degree angle is too shallow, increasing the risk of incorrect placement and ineffective administration of the intradermal injection.
Choice B reason: The 15-degree angle ensures precise intradermal placement, forming a wheal that indicates proper administration into the dermis for optimal absorption.
Choice C reason: A 30-degree angle places the medication too deep into subcutaneous tissue, compromising intended drug absorption.
Choice D reason: A 45-degree angle results in subcutaneous rather than intradermal injection, altering the drug’s effectiveness and purpose.
Correct Answer is C
Explanation
Choice A reason: Toxic effects involve overdose symptoms like coma; staying awake isn’t toxicity, as Nembutal’s sedative intent is reversed, not exaggerated, in this reaction.
Choice B reason: Drug allergy causes immune responses (e.g., rash); insomnia isn’t allergic, but a paradoxical effect, differing from hypersensitivity reactions entirely.
Choice C reason: Idiosyncrasy is an unexpected reaction; Nembutal, a barbiturate, should sedate, but wakefulness is an abnormal, individual response, fitting this category precisely.
Choice D reason: Tolerance reduces efficacy over time; this acute, opposite reaction to a sedative isn’t tolerance, but an immediate, unpredictable drug response.
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