Which statement accurately describes patient tolerance to medications?
The patient will require a stable dose of the medication until the drug is discontinued.
Tolerance occurs when the liver or kidneys are no longer able to metabolize the drug.
The patient will continually require higher doses of the drug for the same effect to be achieved.
Tolerance only develops when the patients do not take the medication as it is prescribed.
The Correct Answer is C
Choice A rationale:
Incorrect. Patients who develop tolerance to a medication do not typically maintain a stable dose over time. Instead, they often require increasing doses to achieve the same effect.
Physiological adaptation: The body adapts to the presence of the medication, leading to a decreased response over time. This adaptation can occur at various levels, including receptor downregulation, changes in enzyme activity, or alterations in neurotransmitter release.
Individual variability: The rate and extent of tolerance development vary significantly among individuals, influenced by factors such as genetics, age, overall health, and medication type.
Choice B rationale:
Incorrect. Impaired liver or kidney function can affect drug metabolism and elimination, but this is not the primary mechanism of tolerance.
Metabolic impairment: Liver or kidney dysfunction can lead to drug accumulation in the body, potentially increasing the risk of side effects or toxicity. However, this does not necessarily cause tolerance, which is a specific phenomenon of decreased responsiveness to the medication's effects.
Choice C rationale:
Correct. This statement accurately describes the hallmark characteristic of tolerance.
Dose escalation: As tolerance develops, patients often require higher doses of the medication to achieve the same therapeutic effect. This can lead to a cycle of increasing doses and potential risks of adverse effects.
Clinical implications: Tolerance is a significant consideration in medication management, as it can affect treatment efficacy, adherence, and the risk of side effects.
Choice D rationale:
Incorrect. Tolerance can develop even when patients adhere strictly to their prescribed medication regimen. It is a physiological phenomenon that is not solely dependent on patient behavior.
Adherence vs. tolerance: While non-adherence can contribute to treatment failure, it is not the underlying cause of tolerance.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Choice A rationale:
Debridement refers to the removal of dead, damaged, or infected tissue to promote healing. It is not a term used to describe skin breakdown caused by moisture.
Choice B rationale:
Evisceration is the protrusion of internal organs through a wound or surgical incision. It is not relevant to the condition of perineal skin breakdown due to wetness.
Choice D rationale:
Dehiscence is the separation of a surgical wound. It is not applicable in this case, as there is no mention of a surgical wound.
Choice C rationale:
Maceration is a term used to describe skin that has become softened and broken down due to prolonged exposure to moisture. This is the most accurate term to describe the condition of perineal skin breakdown after sitting in wet underclothes for many hours.
Key features of maceration:
Skin softening: The skin becomes white and wrinkled, resembling a prune.
Epidermal loss: The outer layer of skin (epidermis) may slough off, leaving the underlying tissue exposed. Redness: The affected area may become red and inflamed.
Pain or tenderness: The area may be painful or tender to the touch.
Increased risk of infection: Macerated skin is more susceptible to infection due to the breakdown of the skin barrier. Causes of maceration:
Prolonged exposure to moisture: This can include sweat, urine, feces, wound drainage, or excessive bathing. Friction: Rubbing or chafing of the skin can also contribute to maceration.
Impaired circulation: Poor blood flow to the area can make it more vulnerable to maceration. Prevention of maceration:
Keep skin clean and dry: This is the most important step in preventing maceration. Change wet or soiled clothing or dressings promptly.
Apply barrier creams or ointments: These can help to protect the skin from moisture.
Use incontinence products: These can help to keep the skin dry if the patient is incontinent. Reposition the patient frequently: This helps to reduce pressure and friction on the skin.
Correct Answer is C
Explanation
Choice A rationale:
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