Which of the following pathophysiological mechanisms contributes to hyperglycemia in type 2 diabetes mellitus?
Autoimmune destruction of pancreatic beta cells.
Increased sensitivity of cells to insulin.
Insulin resistance in target tissues.
Excess insulin production by the pancreas.
The Correct Answer is C
In type 2 diabetes, insulin resistance occurs, meaning that the body's cells do not respond effectively to the action of insulin. This leads to decreased glucose uptake by cells and elevated blood sugar levels.
Incorrect choices:
a. This choice is incorrect. Autoimmune destruction of pancreatic beta cells is characteristic of type 1 diabetes, not type 2.
b. This choice is incorrect. Increased sensitivity of cells to insulin would result in improved glucose uptake and reduced hyperglycemia.
d. This choice is incorrect. Excess insulin production by the pancreas is not a typical mechanism in type 2 diabetes.
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Related Questions
Correct Answer is B
Explanation
Insulin is a hormone produced by the pancreas that plays a crucial role in regulating blood glucose levels. It facilitates glucose uptake into cells, promotes glycogen synthesis in the liver and muscles, and inhibits hepatic glucose production.
Incorrect choices:
a. This choice is incorrect. Glucagon is another pancreatic hormone that increases blood glucose levels by promoting glycogen breakdown and glucose release from the liver.
c. This choice is incorrect. Epinephrine is a hormone produced by the adrenal glands that can raise blood glucose levels during times of stress.
d. This choice is incorrect. Cortisol, also produced by the adrenal glands, can increase blood glucose levels in response to stress and inflammation.
Correct Answer is D
Explanation
Long-standing hyperglycemia in diabetes mellitus can lead to impaired wound healing, as high blood sugar levels affect blood flow and immune function, increasing the risk of infections.
Incorrect choices:
a. This choice is incorrect. Polyuria, polydipsia, and polyphagia are the "three P's" associated with diabetes-related hyperglycemia.
b. This choice is incorrect. Nausea, vomiting, and abdominal pain are not typically related to long-standing hyperglycemia in diabetes.
c. This choice is incorrect. Blurred vision and vision loss are manifestations of diabetic retinopathy, a microvascular complication, rather than impaired wound healing.
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