Which of the following pathophysiological mechanisms contributes to hyperglycemia in type 2 diabetes mellitus?
Autoimmune destruction of pancreatic beta cells.
Increased sensitivity of cells to insulin.
Insulin resistance in target tissues.
Excess insulin production by the pancreas.
The Correct Answer is C
In type 2 diabetes, insulin resistance occurs, meaning that the body's cells do not respond effectively to the action of insulin. This leads to decreased glucose uptake by cells and elevated blood sugar levels.
Incorrect choices:
a. This choice is incorrect. Autoimmune destruction of pancreatic beta cells is characteristic of type 1 diabetes, not type 2.
b. This choice is incorrect. Increased sensitivity of cells to insulin would result in improved glucose uptake and reduced hyperglycemia.
d. This choice is incorrect. Excess insulin production by the pancreas is not a typical mechanism in type 2 diabetes.
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Related Questions
Correct Answer is C
Explanation
Empagliflozin is an SGLT2 inhibitor that reduces renal glucose reabsorption, leading to increased urinary glucose excretion and improved glycemic control in type 2 diabetes mellitus.
Incorrect choices:
a. This choice is incorrect. Metformin primarily improves insulin sensitivity and reduces hepatic glucose production.
b. This choice is incorrect. Glipizide stimulates insulin secretion from pancreatic beta cells.
d. This choice is incorrect. Insulin detemir is a long-acting basal insulin used in insulin therapy.
Correct Answer is A
Explanation
Metformin is a commonly used oral antidiabetic medication that improves insulin sensitivity in peripheral tissues, reduces hepatic glucose production, and enhances glucose uptake by cells.
Incorrect choices:
b. This choice is incorrect. Glipizide is a sulfonylurea medication that stimulates insulin secretion from the pancreas, rather than increasing insulin sensitivity.
c. This choice is incorrect. Insulin lispro is a rapid-acting insulin analog used for mealtime coverage in insulin therapy.
d. This choice is incorrect. Exenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist that stimulates insulin secretion and suppresses glucagon release, but it does not primarily target insulin sensitivity.
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