Which cytotoxic lymphocyte granules contain serine proteases that induce apoptosis in target cells?
Perforins.
Cytokines.
Granzymes.
Interferons.
The Correct Answer is C
Granzymes are a family of serine proteases that are stored in and secreted from the cytotoxic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.
They work in synergy with perforin, a pore-forming toxin, to induce apoptosis in target cells.
Perforin is necessary for the delivery of granzyme B to the target cell cytosol where caspase-dependent and -independent pathways to apoptosis are activated.
Perforins (choice A) are pore-forming toxins that work in synergy with granzymes to induce apoptosis in target cells.
Cytokines (choice B) are signaling molecules that regulate immune responses but do not directly induce apoptosis in target cells.
Interferons (choice D) are a type of cytokine that play a role in immune responses but do not directly induce apoptosis in target cells.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Innate immunity represents the first line of defense to an intruding pathogen.
The innate immune system is a series of nonspecific defenses that make up the innate immune system.
These defenses are not directed against any one pathogen but instead provide a guard against all infection.
Choice A is incorrect because adaptive immunity is activated when pathogens are able to bypass innate immune defenses.
Choice B is incorrect because antibodies are part of the adaptive immune system and are produced by B cells.
Choice D is incorrect because T cells are part of the adaptive immune system and assist B cells or directly kill infected cells.
Correct Answer is A
Explanation
Orthopnea refers to a condition in which a patient experiences difficulty breathing while lying down, but their breathing improves when they sit up or stand.
Choice B, Hypoxia, is not the correct answer because it refers to a condition in which there is a lack of oxygen supply to the body’s tissues.
Choice C, Tachypnea, is not the correct answer because it refers to rapid breathing.
Choice D, Bradypnea, is not the correct answer because it refers to abnormally slow breathing.
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