Which cytotoxic lymphocyte granules contain serine proteases that induce apoptosis in target cells?
Perforins.
Cytokines.
Granzymes.
Interferons.
The Correct Answer is C
Granzymes are a family of serine proteases that are stored in and secreted from the cytotoxic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.
They work in synergy with perforin, a pore-forming toxin, to induce apoptosis in target cells.
Perforin is necessary for the delivery of granzyme B to the target cell cytosol where caspase-dependent and -independent pathways to apoptosis are activated.
Perforins (choice A) are pore-forming toxins that work in synergy with granzymes to induce apoptosis in target cells.
Cytokines (choice B) are signaling molecules that regulate immune responses but do not directly induce apoptosis in target cells.
Interferons (choice D) are a type of cytokine that play a role in immune responses but do not directly induce apoptosis in target cells.
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Related Questions
Correct Answer is D
Explanation
Genes that regulate cell division can become oncogenes when mutated.
Oncogenes are mutated genes that can contribute to the development of cancer.
In their non-mutated state, everyone has genes which are referred to as proto-oncogenes.
When proto-oncogenes are mutated or increased in numbers due to DNA damage, the proteins produced by these genes can affect the growth, proliferation, and survival of the cell, and potentially result in the formation of a malignant tumor.
Choice A is incorrect because mutations in oncogenes do not always result in the inhibition of cell division.
Instead, they can contribute to the development of cancer by affecting cell growth.
Choice B is incorrect because oncogenes are not only found in human cells but can be present in other organisms as well.
Choice C is incorrect because genes that regulate cell division can be found in viruses.
Correct Answer is A
Explanation
The spleen is an organ in the human body that is responsible for the removal of damaged red blood cells and the production of certain types of white blood cells.
Choice B is incorrect because the kidneys are responsible for filtering waste from the blood and regulating electrolyte balance.
Choice C is incorrect because the pancreas produces hormones and enzymes that aid in digestion.
Choice D is incorrect because the thyroid gland produces hormones that regulate metabolism.
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