Which cytotoxic lymphocyte granules contain serine proteases that induce apoptosis in target cells?
Perforins.
Cytokines.
Granzymes.
Interferons.
The Correct Answer is C
Granzymes are a family of serine proteases that are stored in and secreted from the cytotoxic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.
They work in synergy with perforin, a pore-forming toxin, to induce apoptosis in target cells.
Perforin is necessary for the delivery of granzyme B to the target cell cytosol where caspase-dependent and -independent pathways to apoptosis are activated.
Perforins (choice A) are pore-forming toxins that work in synergy with granzymes to induce apoptosis in target cells.
Cytokines (choice B) are signaling molecules that regulate immune responses but do not directly induce apoptosis in target cells.
Interferons (choice D) are a type of cytokine that play a role in immune responses but do not directly induce apoptosis in target cells.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Hydrogen bonds are responsible for the unique properties of water and play a crucial role in the structure of DNA and proteins.
Hydrogen bonds are weak electrostatic attractions between a hydrogen atom covalently bonded to an electronegative atom and another electronegative atom.
Choice B.
Covalent bonds is incorrect because covalent bonds are strong chemical bonds formed by the sharing of electrons between two atoms.
Choice C.
Ionic bonds is incorrect because ionic bonds are chemical bonds formed by the transfer of electrons from one atom to another, resulting in the formation of ions.
Choice D.
Van der Waals forces is incorrect because Van der Waals forces are weak intermolecular forces that arise from temporary dipoles induced in atoms or molecules.
Correct Answer is A
Explanation
The neuromuscular junction is a type of synapse where neuronal signals from the brain or spinal cord interact with skeletal muscle fibers, causing them to contract.
The activation of many muscle fibers together causes muscles to contract, which in turn can produce movement.
Choice B is incorrect because binding acetylcholine to nAChRs is a process that occurs at the neuromuscular junction, but it is not the function of the neuromuscular junction itself.
Choice C is incorrect because depolarizing the muscle cell membrane is a result of the function of the neuromuscular junction, but it is not the function itself.
Choice D is incorrect because activating voltage-gated sodium channels on the muscle membrane is a result of the function of the neuromuscular junction, but it is not the function itself.
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