Which cytotoxic lymphocyte granules contain serine proteases that induce apoptosis in target cells?
Perforins.
Cytokines.
Granzymes.
Interferons.
The Correct Answer is C
Granzymes are a family of serine proteases that are stored in and secreted from the cytotoxic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.
They work in synergy with perforin, a pore-forming toxin, to induce apoptosis in target cells.
Perforin is necessary for the delivery of granzyme B to the target cell cytosol where caspase-dependent and -independent pathways to apoptosis are activated.
Perforins (choice A) are pore-forming toxins that work in synergy with granzymes to induce apoptosis in target cells.
Cytokines (choice B) are signaling molecules that regulate immune responses but do not directly induce apoptosis in target cells.
Interferons (choice D) are a type of cytokine that play a role in immune responses but do not directly induce apoptosis in target cells.
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Related Questions
Correct Answer is C
Explanation
A substitution mutation is a type of point mutation where one base in the DNA sequence is replaced by another base.
Choice A is incorrect because a deletion mutation occurs when one or more bases are removed from the DNA sequence.
Choice B is incorrect because an insertion mutation occurs when one or more bases are added to the DNA sequence.
Choice D is incorrect because an inversion mutation occurs when a segment of DNA is reversed within the chromosome.
Correct Answer is C
Explanation
Inflammatory cytokines released during the early response to bacterial infection play a crucial role in initiating cell recruitment and local inflammation 1.
They induce the expression of adhesion molecules in endothelial cells and promote the recruitment of neutrophils to the site of inflammation 1.
Choice A is incorrect because while inflammatory cytokines may enhance phagocytosis, they do not directly disrupt the infection.
Choice B is incorrect because inflammatory cytokines do not directly attack invading pathogens.
Choice D is incorrect because inflammatory cytokines do not secrete antibodies to neutralize pathogens.
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