Which client statement demonstrates understanding of the nurse’s teaching for levothyroxine (Synthroid)?

Choice A rationale:

Propylthiouracil (PTU) is a thionamide medication that inhibits the synthesis of thyroid hormones. It is the preferred drug for presurgical treatment of Graves' disease because it effectively lowers thyroid hormone levels and reduces the risk of thyroid storm, a life-threatening complication that can occur during or after surgery.

PTU acts by blocking the enzyme thyroid peroxidase, which is essential for the production of thyroid hormones. It also inhibits the conversion of thyroxine (T4) to triiodothyronine (T3), the more active form of thyroid hormone. This results in a decrease in circulating levels of both T4 and T3, leading to a reduction in the symptoms of hyperthyroidism.

PTU is typically started at a dose of 100-300 mg daily, divided into two or three doses. The dose is then adjusted based on the patient's response and thyroid hormone levels. The goal of treatment is to achieve a euthyroid state, which means that the thyroid hormone levels are within the normal range.

PTU is generally well-tolerated, but it can cause some side effects, including skin rash, itching, nausea, vomiting, abdominal pain, joint pain, and hair loss. In rare cases, it can also cause serious side effects, such as liver damage and agranulocytosis (a decrease in white blood cells).

Choice B rationale:

Liotrix (Thyrolar) is a combination of synthetic T4 and T3 hormones. It is not used for presurgical treatment of Graves' disease because it can worsen the symptoms of hyperthyroidism.

Choice C rationale:

Propranolol (Inderal) is a beta-blocker medication that can be used to control the symptoms of hyperthyroidism, such as tachycardia, tremor, and anxiety. However, it does not lower thyroid hormone levels and is not used for presurgical treatment of Graves' disease.

Choice D rationale:

Levothyroxine sodium (Synthroid) is a synthetic T4 hormone. It is used to treat hypothyroidism, but it is not used for presurgical treatment of Graves' disease.

Choice A rationale:

Prednisolone is a corticosteroid that has anti-inflammatory and immunosuppressant effects. It does not have a direct effect on urine output.

While it may be used in some cases of head trauma to reduce inflammation, it would not be the first-line choice to address excessive urine output.

Prolonged use of prednisolone can have adverse effects such as fluid retention, weight gain, hypertension, and hyperglycemia.

Choice B rationale:

Corticotropin (ACTH) is a hormone that stimulates the adrenal glands to produce cortisol. Cortisol has a variety of effects, including increasing blood pressure and blood sugar levels.

It does not have a direct effect on urine output and would not be used to address this issue.

ACTH can have significant side effects, including fluid retention, electrolyte imbalances, and mood changes.

Choice C rationale:

Vasopressin is a hormone that regulates fluid balance in the body. It works by increasing water reabsorption in the kidneys, which can help to reduce urine output.

It is the most appropriate medication to administer to a client with excessive urine output following head trauma.

Vasopressin can be administered intravenously or subcutaneously. It is important to monitor the client's fluid intake and output closely when administering vasopressin, as it can lead to fluid overload if not used carefully.

Choice D rationale:

Calciferol is a form of vitamin D that helps to regulate calcium and phosphorus levels in the body. It does not have a direct effect on urine output.

It would not be used to address excessive urine output in a client with head trauma.

Excessive doses of calciferol can lead to hypercalcemia, which can cause kidney stones, bone pain, and other serious problems.