What concept is considered when generic drugs are substituted for brand-name drugs?

Half Life.

Critical concentration.

Distribution.

Bioavailability.

Answer and Explanation

The Correct Answer is D

Choice A rationale

The half-life of a drug refers to the time it takes for the plasma concentration of a drug to reduce by half. It is not a primary consideration when substituting generic drugs for brand-name drugs.

Choice B rationale

Critical concentration is the amount of a drug needed to achieve therapeutic effects. While important, it is not the main factor in generic substitution.

Choice C rationale

Distribution describes how a drug is dispersed throughout the body's tissues and fluids. This factor is crucial for drug efficacy but not directly related to substituting generic drugs.

Choice D rationale

Bioavailability is the degree and rate at which an active drug ingredient is absorbed and becomes available at the site of action. Generic drugs must have the same bioavailability as brand-name drugs to ensure they are just as effective.

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Correct Answer is D

Explanation

Choice A rationale

Taking medication at the first sign of nausea may be too late to prevent motion sickness as it takes time for the medication to be absorbed and take effect.

Choice B rationale

Taking medication just prior to takeoff might not give the drug enough time to be absorbed and start working effectively.

Choice C rationale

Taking medication just prior to boarding the flight may not provide sufficient time for the drug to reach its peak effectiveness.

Choice D rationale

Taking the medication at 0700 before leaving for the airport allows enough time for the drug to be absorbed and reach its peak effect, which is essential for preventing motion sickness during the flight.

A. Magnesium. B. Sodium. C. Potassium. D. Calcium.

Correct Answer is D

Explanation

Choice A rationale

Magnesium plays a role in various cellular functions, including enzyme activity and muscle contraction, but it does not directly inactivate troponin to enable actin and myosin interaction.

Choice B rationale

Sodium is essential for action potential generation and nerve impulse transmission but does not directly influence troponin activity or muscle contraction through actin and myosin bridge formation.

Choice C rationale

Potassium is critical for maintaining cellular resting membrane potential and repolarization of cells but does not play a direct role in inactivating troponin to facilitate muscle contraction.

Choice D rationale

Calcium is the electrolyte that inactivates troponin, allowing actin and myosin to form cross-bridges and contract muscle fibers. Calcium binds to troponin, causing a conformational change that exposes binding sites for myosin on actin filaments.

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What concept is considered when generic drugs are substituted for brand-name drugs?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A patient who experiences motion sickness when flying asks the nurse the best time to take the medication prescribed to prevent motion sickness for a flight.The nurse will instruct the patient to take the medication at what time?

Correct Answer is D

Explanation

What electrolyte inactivates troponin and allows actin and myosin to form a bridge enabling fibers to contract?

Correct Answer is D

Explanation

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