The emergency department nurse notes that a patient with chronic kidney failure has a potassium level of 6.5 mEq/L. Which medications would the nurse expect to administer? Select all that apply.

Choice A rationale:

Drug/alcohol use: While substance abuse during pregnancy can lead to adverse outcomes such as preterm labor, fetal growth restriction, and birth defects, it is not considered a primary factor in determining high-risk status for this patient. The specific substances involved (cocaine and alcohol) are indeed associated with risks, but they are not as significant as other factors in this case.

Age: The patient's age of 24 is not considered a high-risk factor for pregnancy. Advanced maternal age (typically defined as 35 years or older) is associated with increased risks for chromosomal abnormalities and other complications, but this patient falls below that age threshold.

Family history: Family history of diabetes mellitus, cancer, and neural tube defects can be relevant to pregnancy risk, but in this case, other factors outweigh their significance.

Choice B rationale:

Blood pressure: The patient's blood pressure of 108/70 mm Hg is within the normal range and does not contribute to highrisk categorization. High blood pressure (hypertension) during pregnancy can lead to preeclampsia and other complications, but this patient does not present with hypertension.

Age: As explained in Choice A, the patient's age is not a high-risk factor.

BMI: A BMI of 17 is considered underweight, which can increase the risk of certain pregnancy complications such as preterm birth and low birth weight. However, in this case, other factors are more significant in determining high-risk status.

Choice C rationale:

Family history: The patient's family history of a neural tube defect (NTD) in a close relative is a significant risk factor for NTDs in her own pregnancy. NTDs are serious birth defects that affect the brain and spinal cord, and they can have lifelong implications for the child. This factor alone warrants a high-risk categorization.

BMI: The patient's underweight BMI of 17 further contributes to her high-risk status, as it can increase the likelihood of certain complications as mentioned earlier.

Drug/alcohol abuse: The patient's admission of cocaine and alcohol use, even if occasional, is a concerning factor for pregnancy. Cocaine, in particular, is a potent vasoconstrictor that can negatively impact fetal growth and development. Alcohol consumption during pregnancy can lead to fetal alcohol spectrum disorders (FASDs), which can cause a range of physical, cognitive, and behavioral problems.

Choice D rationale:

Age: As explained previously, the patient's age is not a high-risk factor.

BMI: The patient's BMI is a contributing factor, but not the most significant one in this case.

Family history: The patient's family history is relevant, but the presence of a neural tube defect in a close relative is the most significant aspect of her family history in terms of pregnancy risk.

correct answer/s is A and D.

Choice A rationale:

Prostaglandins:

Mechanism of action: Prostaglandins are hormone-like substances that play a crucial role in labor initiation. They act by softening and ripening the cervix, stimulating uterine contractions, and rupturing the amniotic sac.

Types: Prostaglandins used for labor induction include:

Dinoprostone (Cervidil, Prepidil): Inserted into the vagina as a gel or pessary.

Misoprostol (Cytotec): Administered orally or vaginally.

Effectiveness: Generally effective in initiating labor within 24 hours, with success rates ranging from 60-85%.

Advantages:

Can be used when the cervix is unfavorable (not ripe).

Can be administered in a variety of ways to suit the patient's preferences.

May have a lower risk of uterine hyperstimulation compared to oxytocin.

Disadvantages:

Can cause side effects such as nausea, vomiting, diarrhea, and fever.

May increase the risk of uterine rupture, especially in women with a history of cesarean delivery.

Choice D rationale:

Amnioinfusion:

Procedure: Involves the infusion of sterile saline solution into the amniotic sac through a small catheter.

Mechanism of action: Not fully understood, but it's thought to work by:

Increasing amniotic fluid volume, which can help to stimulate contractions.

Stretching the uterine walls, which may trigger the release of prostaglandins.

Reducing pressure on the umbilical cord, which can improve fetal oxygenation.

Effectiveness: Usually used in conjunction with other induction methods, such as oxytocin or prostaglandins. Has a success rate of about 50-60% in initiating labor within 24 hours.

Advantages:

May be helpful in cases of low amniotic fluid (oligohydramnios).

Can decrease the risk of umbilical cord compression.

Disadvantages:

Requires the insertion of a catheter into the uterus, which carries a small risk of infection.

May cause discomfort for the mother.