Interpret and spell the abbreviation: supp_____

Enter the full word below.

A. Liver failure does not have a direct contraindication with bronchodilators, though careful monitoring is needed.

B. Renal failure is not a direct contraindication for bronchodilator use; however, kidney function can affect drug metabolism and clearance.

C. Respiratory failure may necessitate bronchodilator therapy rather than caution, especially in conditions like COPD or asthma where bronchodilators are crucial for management.

D. Heart failure requires caution with bronchodilators because they can lead to increased heart rate and blood pressure, potentially exacerbating heart failure symptoms or leading to arrhythmias.

A. A drug that binds tightly to protein is typically released slowly, not quickly, as it remains bound in circulation.

B. Tight binding to proteins usually results in a prolonged duration of action since the drug is released gradually into the bloodstream, leading to sustained therapeutic effects.

C. Drugs that bind tightly to protein are generally not excreted quickly; they remain in circulation longer due to the binding.

D. While toxicity can occur with any drug, tight protein binding does not inherently lead to toxicity; it primarily affects the pharmacokinetics of the drug.