A patient who is HIV-positive has been receiving medication therapy that includes zidovudine.

The prescriber has decided to stop the zidovudine due to its dose-limiting adverse effect.

Which of these conditions is the dose-limiting adverse effect of zidovudine therapy?

Bone marrow suppression

Retinitis

Renal toxicity

Hepatotoxicity

Answer and Explanation

The Correct Answer is A

Choice A rationale:

Zidovudine, also known as AZT, is a medication used for the treatment of human immunodeficiency virus (HIV) infection. One of the major dose-limiting toxic effects of Zidovudine is hematologic toxicity, which manifests clinically as anemia, neutropenia, and sometimes as platelet deficits with onset after several weeks of treatment. This hematologic toxicity is essentially a form of bone marrow suppression. Therefore, bone marrow suppression is the dose-limiting adverse effect of zidovudine therapy.

Choice B rationale:

Retinitis is not a known dose-limiting adverse effect of zidovudine. While zidovudine has a range of side effects, retinitis is not commonly associated with its use.

Choice C rationale:

Renal toxicity is not a known dose-limiting adverse effect of zidovudine. While zidovudine can have various side effects, renal toxicity is not typically one of them.

Choice D rationale:

Hepatotoxicity is not the dose-limiting adverse effect of zidovudine. While severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of zidovudine, it is not considered the dose-limiting adverse effect. The dose-limiting adverse effect is more specifically related to hematologic toxicity, which includes bone marrow suppression.

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Free Nursing Study Resources

Correct Answer is ["50 "]

Explanation

The question is about calculating the volume of phenytoin oral solution that the nurse should administer per dose. The client is prescribed 250 mg of phenytoin and the available solution has a concentration of 25 mg/5 mL.

Let’s calculate the volume step by step:

Step 1: Identify the prescribed dose and the concentration of the available medication. The prescribed dose is 250 mg and the concentration of the available medication is 25 mg/5 mL.

Step 2: Set up the calculation. We want to find out how many mL correspond to the prescribed dose. We can set up the calculation as follows: (Prescribed dose ÷ Concentration) × Volume.

Step 3: Substitute the known values into the calculation. This gives us: (250 mg ÷ 25 mg/5 mL).

Step 4: Perform the division operation first due to the order of operations (BIDMAS/BODMAS). This gives us: (250 mg ÷ 5 mg/mL).

Step 5: Perform the final calculation. This gives us: 50 mL.

So, the nurse should administer 50 mL of the phenytoin oral solution per dose.

Please note that this calculation assumes that the prescribed dose (250 mg) is to be administered in one go. If the dose is to be split over the day, the volume to be administered would change accordingly.

Correct Answer is ["0.6 "]

Explanation

Answer and explanation

The question is about calculating the volume of methylnaltrexone to administer to a client. The client needs a dose of 12 mg, and the available methylnaltrexone is 8 mg/0.4 mL.

Let’s calculate the volume step by step:

Step 1: Identify the given values:

Desired dose (D) = 12 mg
Available dose (A) = 8 mg
Volume for available dose (V) = 0.4 mL

Step 2: Use the given values in the formula for calculating the volume to administer:

Volume to administer=Available doseDesired dose×Volume for available dose Step 3: Substitute the given values into the formula:

Volume to administer=(12*0.4)/8

Step 4: Perform the multiplication and division:

Volume to administer=4.8mL/8

Step 5: Simplify the division to find the volume to administer:

Volume to administer=0.6mL

So, the nurse should administer 0.6 mL of methylnaltrexone to the client.

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A patient who is HIV-positive has been receiving medication therapy that includes zidovudine. The prescriber has decided to stop the zidovudine due to its dose-limiting adverse effect. Which of these conditions is the dose-limiting adverse effect of zidovudine therapy?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is caring for a client who is to receive liquid medications via a gastrostomy tube. The client is prescribed phenytoin 250 mg. The amount available is phenytoin oral solution 25 mg/5 mL. How many mL should the nurse administer per dose?

Correct Answer is ["50 "]

Explanation

A nurse is preparing to administer methylnaltrexone 12 mg subcutaneously to a client who has opioid-induced constipation. The available methylnaltrexone is 8 mg/0.4 mL. How many mL should the nurse administer? (Round the answer to the nearest tenth. Use a leading zero if it applies.

Correct Answer is ["0.6 "]

Explanation

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A patient who is HIV-positive has been receiving medication therapy that includes zidovudine.

The prescriber has decided to stop the zidovudine due to its dose-limiting adverse effect.

Which of these conditions is the dose-limiting adverse effect of zidovudine therapy?