A patient who is HIV-positive has been receiving medication therapy that includes zidovudine.

The prescriber has decided to stop the zidovudine due to its dose-limiting adverse effect.

Which of these conditions is the dose-limiting adverse effect of zidovudine therapy?

Bone marrow suppression

Retinitis

Renal toxicity

Hepatotoxicity

Answer and Explanation

The Correct Answer is A

Choice A rationale:

Zidovudine, also known as AZT, is a medication used for the treatment of human immunodeficiency virus (HIV) infection. One of the major dose-limiting toxic effects of Zidovudine is hematologic toxicity, which manifests clinically as anemia, neutropenia, and sometimes as platelet deficits with onset after several weeks of treatment. This hematologic toxicity is essentially a form of bone marrow suppression. Therefore, bone marrow suppression is the dose-limiting adverse effect of zidovudine therapy.

Choice B rationale:

Retinitis is not a known dose-limiting adverse effect of zidovudine. While zidovudine has a range of side effects, retinitis is not commonly associated with its use.

Choice C rationale:

Renal toxicity is not a known dose-limiting adverse effect of zidovudine. While zidovudine can have various side effects, renal toxicity is not typically one of them.

Choice D rationale:

Hepatotoxicity is not the dose-limiting adverse effect of zidovudine. While severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of zidovudine, it is not considered the dose-limiting adverse effect. The dose-limiting adverse effect is more specifically related to hematologic toxicity, which includes bone marrow suppression.

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Correct Answer is C

Explanation

Choice A rationale:

Administering the medications using a 3-mL medication syringe is not the best practice. While it is possible to use a 3-mL syringe for medication administration, it is not the most efficient or safest method. A larger syringe allows for easier administration and reduces the risk of creating too much pressure which could potentially damage the PEG tube.

Choice B rationale:

Applying firm pressure on the syringe’s piston to infuse the medication is not recommended. This can create too much pressure in the PEG tube and could potentially cause damage. It is generally advised to allow the medication to flow into the tube via gravity. Choice C rationale:

Flushing the tubing with 30 mL of saline after the medication has been given is the correct technique. This helps to ensure that all of the medication has been administered and also helps to keep the tube clear of any potential blockages.

Choice D rationale:

Using the barrel of the syringe, allowing the medication to flow via gravity into the tube is a common practice. However, it is not the only step in the process. It is also important to flush the tube before and after medication administration to ensure all medication is delivered and to maintain the patency of the tube.

A. Polyuria B. Sweating C. Tachycardia D. Blurry vision

Correct Answer is ["B","C","D"]

Explanation

Choice A rationale:

Polyuria, which is frequent or excessive urination, is not typically a symptom of hypoglycemia. It is more commonly associated with hyperglycemia, or high blood sugar levels.

Choice B rationale:

Sweating is indeed a common symptom of hypoglycemia. When blood sugar levels fall too low, the body may respond by sweating as it releases adrenaline in response to the hypoglycemic state.

Choice C rationale:

Tachycardia, or a fast heartbeat, is another common symptom of hypoglycemia. This is part of the body’s response to low blood sugar levels, as it releases adrenaline to try to raise these levels.

Choice D rationale:

Blurry vision can be a symptom of hypoglycemia. When blood sugar levels fall, it can affect the ability of the eyes to focus, leading to blurry vision.

Choice E rationale:

Polydipsia, or excessive thirst, is not typically a symptom of hypoglycemia. Like polyuria, it is more commonly associated with hyperglycemia.

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A patient who is HIV-positive has been receiving medication therapy that includes zidovudine. The prescriber has decided to stop the zidovudine due to its dose-limiting adverse effect. Which of these conditions is the dose-limiting adverse effect of zidovudine therapy?

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The nurse is administering liquid medications through a percutaneous endoscopic gastrostomy (PEG) tube. Which technique is correct?

Correct Answer is C

Explanation

A nurse is reinforcing teaching with a client who has type 2 diabetes mellitus. The nurse determines that teaching has been effective when the client identifies which of the following manifestations of hypoglycemia? (Select all that apply.)

Correct Answer is ["B","C","D"]

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A patient who is HIV-positive has been receiving medication therapy that includes zidovudine.

The prescriber has decided to stop the zidovudine due to its dose-limiting adverse effect.

Which of these conditions is the dose-limiting adverse effect of zidovudine therapy?