A nurse is reviewing the results of an Alpha-fetoprotein Test (AFP) with a pregnant client.
What does a low level of AFP (<0.5 MoM) potentially indicate?
Neural tube defect.
Chromosomal abnormality.
Maternal weight-related factors.
Fetal demise.
The Correct Answer is B
A low level of AFP (<0.5 MoM) in a pregnant woman can indicate that the fetus has a chromosomal abnormality, such as Down syndrome or Edwards syndrome.
This is because these conditions affect the development of the fetal liver, which produces AFP.
Choice A is wrong because neural tube defects, such as spina bifida, are associated with high levels of AFP (>2.5 MoM) in the maternal blood.
This is because AFP can leak from the open spinal canal of the fetus into the amniotic fluid and then into the maternal blood.
Choice C is wrong because maternal weight-related factors do not affect the level of AFP in the maternal blood.
However, they can affect the interpretation of the AFP test results, as the test needs to be adjusted for maternal weight, age, ethnicity, and gestational age.
Choice D is wrong because fetal demise (death) can also cause high levels of AFP in the maternal blood, as the AFP from the dead fetus can leak into the amniotic fluid and then into the maternal blood.
Normal ranges of AFP in pregnant women vary depending on the gestational age and the method of measurement.
Generally, normal levels of AFP are below 10 ng/ml in nonpregnant adults and below 2.5 MoM in pregnant women.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
An equivocal CST indicates late decelerations of the FHR with less than 50% of contractions.
This means that the fetus may have some degree of hypoxia or distress, but not enough to warrant immediate delivery.
An equivocal CST may also result from hyperstimulation of the uterus, which can cause excessive contractions and reduce blood flow to the placenta.
Choice B is wrong because late decelerations of the FHR with at least 50% of contractions is a positive CST, which indicates a high risk of fetal death due to hypoxia and is a contraindication to labor.
Choice C is wrong because no late decelerations of the FHR during contractions is a negative CST, which indicates a good fetal wellbeing and tolerance of labor.
Choice D is wrong because variable decelerations of the FHR with or without contractions are not related to uterine activity and may indicate cord compression or other fetal problems.
Variable decelerations are not used to interpret CST results.
Correct Answer is A
Explanation
An alpha-fetoprotein test (AFP) is a blood test that measures the amount of AFP present in blood.
It’s usually part of what’s called a triple screen or quad screen in the second trimester of pregnancy.
The yolk sac, GI tract, and liver of an unborn baby produce AFP.
It then circulates through the fetal and maternal blood.
High levels of AFP in pregnant people can indicate that the baby has a neural tube defect, such as spina bifida or anencephaly.
Choice B is wrong because assessing placental function is not the primary purpose of an AFP test.
However, low levels of AFP can indicate problems with the placenta or the baby’s growth.
Choice C is wrong because determining fetal gender is not the primary purpose of an AFP test.
However, some genetic tests that use a sample of the baby’s DNA from the pregnant person’s blood can reveal the baby’s sex as early as 10 weeks of pregnancy.
Choice D is wrong because diagnosing chromosomal abnormalities is not the primary purpose of an AFP test.
However, an AFP test is usually part of a quad screen that also tests for other markers that can indicate the risk of chromosomal abnormalities, such as Down syndrome.
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