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A nurse is preparing to administer vancomycin IV to a client. Which of the following medications may interact with vancomycin?

A.

Nitroglycerin

B.

Furosemide

C.

Calcium chloride

D.

Morphine

Answer and Explanation

The Correct Answer is B

A. Nitroglycerin: Nitroglycerin is a vasodilator used to treat angina and does not have known interactions with vancomycin. Concurrent use does not increase the risk of vancomycin toxicity or adverse effects.

B. Furosemide: Furosemide is a loop diuretic that can be nephrotoxic and ototoxic, similar to vancomycin. Using both medications concurrently increases the risk of kidney damage and hearing loss, requiring careful monitoring of renal function and auditory status.

C. Calcium chloride: Calcium chloride is used for hypocalcemia and cardiac stabilization but does not interact directly with vancomycin. No enhanced toxicity or adverse reaction is expected when these drugs are administered together.

D. Morphine: Morphine is an opioid analgesic with no direct interaction with vancomycin. While both drugs may depress the central nervous system in different ways, morphine does not increase the risk of vancomycin-related nephrotoxicity or ototoxicity.


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Related Questions

Correct Answer is C

Explanation

A. "I have vomited several times.": Vomiting can be a side effect of penicillin, but it is usually manageable and not immediately life-threatening unless severe dehydration occurs.

B. "I am having diarrhea.": Mild diarrhea is a common side effect of antibiotics. It is important to monitor for signs of C. difficile infection, but occasional loose stools are not immediately critical.

C. "I am having trouble swallowing.": Difficulty swallowing may indicate oropharyngeal edema, which can be a sign of a severe allergic reaction to penicillin. This requires immediate attention as it can progress to airway obstruction.

D. "My skin feels itchy all over.": Generalized itching may indicate a mild allergic reaction. While it should be monitored, it is less urgent than symptoms suggesting airway compromise.

Correct Answer is B

Explanation

A. Increased calcium level: Furosemide is a loop diuretic that promotes the excretion of electrolytes, including calcium. An increased calcium level would not indicate a therapeutic response and may suggest another metabolic issue.

B. Decreased urine specific gravity: Furosemide increases urine output by inhibiting sodium and water reabsorption in the loop of Henle. A decreased urine specific gravity reflects more dilute urine, which indicates effective diuresis and a therapeutic response.

C. Decreased liver enzymes: Furosemide does not have a direct effect on liver enzyme levels. Changes in liver enzymes would not reflect the effectiveness of the diuretic therapy.

D. Increased serum sodium level: Loop diuretics like furosemide can lead to sodium loss rather than an increase. An elevated serum sodium level would not indicate a therapeutic effect of the medication.

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