. A nurse is preparing to administer filgrastim 5 mcg/kg/day subcutaneous to a client who weighs 143 lb. How many mcg should the nurse administer per day? (Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.) _mcg

A) Stroke volume: Stroke volume is the amount of blood ejected from the heart with each contraction, and it's an essential parameter in assessing cardiac function. However, when titrating a nitroprusside infusion, the primary goal is to manage blood pressure rather than directly targeting stroke volume. Nitroprusside is primarily used as a vasodilator to lower blood pressure in hypertensive emergencies. While changes in blood pressure may indirectly affect stroke volume, blood pressure itself is the primary parameter for titration.

B) Cardiac output: Cardiac output, which is the volume of blood pumped by the heart per minute, may be affected by nitroprusside due to its vasodilatory effects. However, like stroke volume, cardiac output is not typically the primary parameter for titrating a nitroprusside infusion. Blood pressure is a more direct indicator of the drug's effect on vascular tone and perfusion pressure.

C) Urine output: Monitoring urine output is crucial for assessing renal function and fluid status, but it is not the primary parameter used to titrate a nitroprusside infusion. While nitroprusside may affect renal blood flow and urine output indirectly, blood pressure remains the immediate indicator of the drug's hemodynamic effects.

D) Blood pressure: Nitroprusside is a potent vasodilator commonly used to lower blood pressure in hypertensive emergencies. Therefore, the primary assessment parameter for titrating a nitroprusside infusion is blood pressure. The nurse should monitor the client's blood pressure frequently and adjust the infusion rate accordingly to achieve the desired therapeutic effect while avoiding hypotension or excessive lowering of blood pressure.

A) Wear gloves when handling the medication: This is the correct action to take when preparing to administer a hazardous IV medication. Wearing gloves helps protect the nurse from direct contact with the medication, reducing the risk of exposure to potentially harmful substances.

B) Administer the medication in a negative pressure room: While some hazardous medications may require administration in a negative pressure room to prevent the spread of airborne contaminants, this is not a standard precaution for administering IV medications. Negative pressure rooms are typically used for airborne infection isolation rather than for medication administration.

C) Administer the medication while wearing protective footwear: While wearing appropriate footwear is important for general safety in healthcare settings, it is not specifically required for administering hazardous IV medications. Protective footwear may be necessary in certain situations, such as when handling biohazardous materials or when there is a risk of spills, but it is not directly related to IV medication administration.

D) Wear an N95 respiratory mask when administering the medication: While respiratory protection may be necessary when handling certain hazardous substances, such as those that produce airborne particles or aerosols, it is not typically required for administering IV medications. N95 masks are primarily used for respiratory protection in situations where there is a risk of inhaling airborne contaminants, such as infectious agents or hazardous chemicals.