A nurse is caring for a client who is receiving morphine via a PCA pump. The nurse should monitor for which of the following as adverse effects of this medication? Select all that apply

Otic medication administration involves the instillation of sterile or non-sterile solutions into the external auditory canal. Proper positioning of the auricleis essential to straighten the ear canal and ensure the medication reaches the tympanic membrane.

Rationale:

A.Pulling the pinna up and back is the correct technique for an adult client to straighten the external auditory canal. This maneuver allows the drops to flow freely toward the eardrum rather than becoming trapped in the curves of the canal. For children under the age of 3, the nurse should teach the caregiver to pull the pinna down and back instead to achieve the same result.

B.Lying flat in bed is not the ideal position for receiving otic drops, as the medication may not flow deep enough into the canal. The client should be in a side-lying position with the affected ear facing upward to facilitate the gravitational flow of the solution. This position should be maintained for several minutes after instillation to ensure maximum absorption and prevent the medication from leaking out.

C.Cooling otic drops before administration is incorrect because cold solutions can cause extreme discomfort and trigger a vestibular response known as the caloric reflex. This reflex can result in severe vertigo, nausea, and nystagmus. Caregivers should be instructed to warm the medication container by rolling it between their hands to reach body temperature, ensuring a more comfortable and safe administration.

D.Tilting the head back is a technique used for ophthalmic or nasal instillations rather than otic medications. For the ear, the head must be tilted toward the opposite shoulder so the affected ear is horizontal and pointing toward the ceiling. Tilting the head backward would cause the drops to run down the side of the face rather than entering the ear canal effectively.

Simvastatin is an HMG-CoA reductase inhibitorused to treat dyslipidemia by reducing hepatic cholesterol synthesis. While effective for cardiovascular prophylaxis, it carries risks of hepatotoxicityand myopathy. Clinical monitoring focuses on liver function tests and markers of muscle integrity to detect early signs of statin-inducedorgan injury.

Rationale:

A.Decreased creatine kinase (CK) is not a finding of clinical concern; however, increased CK would be highly significant. Elevated CK levels indicate muscle breakdown or rhabdomyolysis, which is a rare but severe side effect of statin therapy. A low or normal CK level suggests that the medication is not currently causing significant damage to the client's skeletal muscle tissue.

B.Increased alkaline phosphatase is a marker of potential liver injury or biliary obstruction and must be reported to the provider immediately. Since simvastatin is processed by the liver, it can cause asymptomatic elevations in liver enzymes or, in rare cases, drug-induced hepatitis. The nurse must monitor for jaundice and upper quadrant pain when these laboratory values are elevated.

C.Increased HDL is a positive therapeutic outcome of simvastatin therapy and does not need to be reported as an adverse finding. High-density lipoprotein is the "good" cholesterol that aids in the transport of cholesterol away from the arteries. An increase in this value indicates that the medication and lifestyle changes are successfully reducing the client's overall cardiovascular risk profile.

D.Decreased HbA1c is generally a favorable finding, as it indicates improved long-term glucose control. Statins have actually been associated with a slight increase in HbA1c and blood glucose levels in some patients, potentially increasing the risk of diabetes. Therefore, a decrease would not be considered a medication-related adverse effect that requires urgent notification to the healthcare provider.