A nurse is administering a proton pump inhibitor (PPI) to a client with gastroesophageal reflux disease (GERD). Which of the following instructions should the nurse provide to the client?

A) Correct. Antidiarrheal medications can cause constipation as an adverse effect.These medications slow down the movement of the gastrointestinal tract, which can lead to a delay in bowel movements and the potential for constipation.
B) Incorrect. Urinary retention is not a common adverse effect of antidiarrheal medications. Instead, urinary retention is associated with medications such as anticholinergics or opioids.
C ) Incorrect. Hypertension is not a typical adverse effect of antidiarrheal medications.
D) Incorrect. Diuresis, which refers to increased urine production, is not associated with antidiarrheal medications. Diuresis is more commonly associated with diuretic medications.

B) Correct. Proton pump inhibitors (PPIs) are most effective when taken on an empty stomach, about 30 minutes before a meal. This ensures optimal absorption and inhibits gastric acid secretion during mealtime.

A) Incorrect. PPIs do not need to be taken with a full glass of water. However, taking them with a small amount of water is recommended to aid in swallowing.

C) Incorrect. PPIs should not be crushed. They are usually in delayed-release or enteric-coated form to protect the medication from stomach acid and facilitate absorption in the small intestine.

D) Incorrect. Taking PPIs right before bedtime is not necessary or recommended unless specifically prescribed by the healthcare provider.