A client has been prescribed an oral drug that is known to have a high first-pass effect. Which measure has the potential to increase the amount of the free drug that is available to body cells?

giving the drug with food in order to delay absorption

administering the drug in small, frequent doses

limiting the client's protein intake and encouraging fluids

administering the drug intravenously rather than orally

Answer and Explanation

The Correct Answer is D

A. Giving the drug with food may delay absorption but does not affect the extent of the first-pass effect.

B. Administering the drug in small, frequent doses may help maintain therapeutic levels but will not significantly alter the first-pass effect.

C. Limiting protein intake could reduce drug binding to proteins, but this is not a standard approach for managing first-pass metabolism.

D. Administering the drug intravenously bypasses the gastrointestinal tract and liver, avoiding the first-pass effect, thereby increasing the amount of free drug available to body cells.

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Correct Answer is A

Explanation

A. Nitroglycerin is contraindicated with erectile dysfunction medications such as sildenafil (Viagra) because both can cause significant drops in blood pressure when used together, potentially leading to severe cardiovascular complications.

B. Furosemide is a diuretic and does not have a direct contraindication with erectile dysfunction medications, although it may contribute to electrolyte imbalances.

C. Verapamil is a calcium channel blocker that does not directly contraindicate the use of erectile dysfunction medications but should be monitored for potential interactions affecting heart rate and blood pressure.

D. Acetaminophen is a pain reliever and does not pose a contraindication for erectile dysfunction medications.

A. Reye syndrome B. Excess antiplatelet action C. Asthma D. Salicylate poisoning

Correct Answer is A

Explanation

A. Reye syndrome is correct because administering aspirin to children, especially during viral illnesses like the flu, can lead to this serious and potentially fatal condition characterized by acute encephalopathy and liver failure.

B. Excess antiplatelet action is incorrect; while aspirin does have antiplatelet effects, this is not the primary concern in a child with a viral illness.

C. Asthma is incorrect; while some individuals with asthma may have sensitivity to aspirin, it is not specifically related to the child's flulike illness.

D. Salicylate poisoning is incorrect; while high doses of aspirin can lead to toxicity, the immediate risk in the context of flu-like illness is Reye syndrome, which is a more specific concern.

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A client has been prescribed an oral drug that is known to have a high first-pass effect. Which measure has the potential to increase the amount of the free drug that is available to body cells?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A male client is concerned with the inability to have an erection and asks for medication to help with this problem. Which information in the client's medication record would contraindicate the client from being prescribed medication for this condition?

Correct Answer is A

Explanation

Correct Answer is A

Explanation

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