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Adverse effects of NSAIDs
Adverse effects of NSAIDs ( 3 Questions)
A nurse is teaching a client who has peptic ulcer disease and is prescribed misoprostol (Cytotec), a synthetic prostaglandin. What should the nurse include in the teaching?
The drug does not have anti-inflammatory and analgesic effects by blocking the production of prostaglandins. On the contrary, it stimulates the production of prostaglandins to protect the stomach lining. Blocking the production of prostaglandins would increase the risk of ulcers.
The drug does not have antipyretic and antiplatelet effects by blocking the production of prostaglandins. Antipyretic means reducing fever, and antiplatelet means preventing blood clots. Misoprostol does not have these effects, and blocking the production of prostaglandins would not cause them either.
Misoprostol is a synthetic prostaglandin that works by "replacing" prostaglandins whose production is blocked by aspirin or NSAIDs¹. Prostaglandins are hormone-like substances that help protect the stomach lining from damage caused by acid and pepsin². Misoprostol produces a dose-related inhibition of gastric acid and pepsin secretion and enhances mucosal resistance to injury¹.
The drug does not have renal protective effects by stimulating the production of prostaglandins. Renal means related to the kidneys, and misoprostol does not affect the kidneys. Stimulating the production of prostaglandins would not protect the kidneys either.
Misoprostol is a synthetic prostaglandin that works by "replacing" prostaglandins whose production is blocked by aspirin or NSAIDs¹. Prostaglandins are hormone-like substances that help protect the stomach lining from damage caused by acid and pepsin². Misoprostol produces a dose-related inhibition of gastric acid and pepsin secretion and enhances mucosal resistance to injury¹.
The other options are incorrect because:
- A. The drug does not have anti-inflammatory and analgesic effects by blocking the production of prostaglandins. On the contrary, it stimulates the production of prostaglandins to protect the stomach lining. Blocking the production of prostaglandins would increase the risk of ulcers.
- B. The drug does not have antipyretic and antiplatelet effects by blocking the production of prostaglandins. Antipyretic means reducing fever, and antiplatelet means preventing blood clots. Misoprostol does not have these effects, and blocking the production of prostaglandins would not cause them either.
- D. The drug does not have renal protective effects by stimulating the production of prostaglandins. Renal means related to the kidneys, and misoprostol does not affect the kidneys. Stimulating the production of prostaglandins would not protect the kidneys either.