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Adverse effects of corticosteroids and immunosuppressants
Adverse effects of corticosteroids and immunosuppressants ( 5 Questions)
A nurse is caring for a client who has systemic lupus erythematosus and is prescribed prednisone, a glucocorticoid. What are some of the indications of prednisone in this condition? (Select all that apply)
It prevents or treats transplant rejection by suppressing the immune response to the foreign antigens on the donor organ is not an indication of prednisone in systemic lupus erythematosus. This is an indication of prednisone in organ transplantation, which is a different condition. Organ transplantation involves replacing a diseased or damaged organ with a healthy one from a donor. The immune system may recognize the donor organ as foreign and attack it, causing transplant rejection. Prednisone can prevent or treat transplant rejection by suppressing the immune response to the foreign antigens on the donor organ .
It reduces the immune-mediated damage to the self-tissues by inhibiting the synthesis of inflammatory mediators and suppressing the activation and proliferation of immune cells . Systemic lupus erythematosus is an autoimmune disease that affects multiple organ systems. It is characterized by autoantibody production that targets the self-tissues and causes inflammation and tissue damage. Prednisone is a glucocorticoid that works by inhibiting the synthesis of cytokines, chemokines, and other inflammatory mediators that mediate the immune response. Prednisone also suppresses the activation and proliferation of T cells, B cells, macrophages, and other immune cells that are involved in the pathogenesis of systemic lupus erythematosus .
It reduces the inflammation and allergic reactions by inhibiting the synthesis of prostaglandins and leukotrienes . Prostaglandins and leukotrienes are lipid-derived inflammatory mediators that are involved in pain, fever, vasodilation, edema, and bronchoconstriction. Prednisone inhibits the enzyme cyclooxygenase (COX), which is responsible for converting arachidonic acid into prostaglandins. Prednisone also inhibits the enzyme 5-lipoxygenase, which is responsible for converting arachidonic acid into leukotrienes. By inhibiting these enzymes, prednisone reduces the production of prostaglandins and leukotrienes and their associated inflammatory and allergic effects .
It kills or inhibits the growth of malignant cells by interfering with the synthesis of nucleic acids is not an indication of prednisone in systemic lupus erythematosus. This is an indication of prednisone in cancer, which is a different condition. Cancer involves abnormal or uncontrolled growth of cells that invade and destroy normal tissues. Prednisone can kill or inhibit the growth of malignant cells by interfering with the synthesis of nucleic acids, which are essential for cell division and replication .
- It reduces the immune-mediated damage to the self-tissues by inhibiting the synthesis of inflammatory mediators and suppressing the activation and proliferation of immune cells . Systemic lupus erythematosus is an autoimmune disease that affects multiple organ systems. It is characterized by autoantibody production that targets the self-tissues and causes inflammation and tissue damage. Prednisone is a glucocorticoid that works by inhibiting the synthesis of cytokines, chemokines, and other inflammatory mediators that mediate the immune response. Prednisone also suppresses the activation and proliferation of T cells, B cells, macrophages, and other immune cells that are involved in the pathogenesis of systemic lupus erythematosus .
- It reduces the inflammation and allergic reactions by inhibiting the synthesis of prostaglandins and leukotrienes . Prostaglandins and leukotrienes are lipid-derived inflammatory mediators that are involved in pain, fever, vasodilation, edema, and bronchoconstriction. Prednisone inhibits the enzyme cyclooxygenase (COX), which is responsible for converting arachidonic acid into prostaglandins. Prednisone also inhibits the enzyme 5-lipoxygenase, which is responsible for converting arachidonic acid into leukotrienes. By inhibiting these enzymes, prednisone reduces the production of prostaglandins and leukotrienes and their associated inflammatory and allergic effects .
The other options are incorrect because:
- A. It prevents or treats transplant rejection by suppressing the immune response to the foreign antigens on the donor organ is not an indication of prednisone in systemic lupus erythematosus. This is an indication of prednisone in organ transplantation, which is a different condition. Organ transplantation involves replacing a diseased or damaged organ with a healthy one from a donor. The immune system may recognize the donor organ as foreign and attack it, causing transplant rejection. Prednisone can prevent or treat transplant rejection by suppressing the immune response to the foreign antigens on the donor organ .
- D. It kills or inhibits the growth of malignant cells by interfering with the synthesis of nucleic acids is not an indication of prednisone in systemic lupus erythematosus. This is an indication of prednisone in cancer, which is a different condition. Cancer involves abnormal or uncontrolled growth of cells that invade and destroy normal tissues. Prednisone can kill or inhibit the growth of malignant cells by interfering with the synthesis of nucleic acids, which are essential for cell division and replication .