Cyanotic and acyanotic congenital heart diseases
- Cyanotic and acyanotic congenital heart diseases are two types of heart defects that are present at birth. They affect the way blood flows through the heart and the rest of the body.
- Cyanotic congenital heart disease (CCHD) reduces the amount of oxygen delivered to the body, causing a bluish tint in the skin, lips, and nails (cyanosis). Acyanotic congenital heart disease (ACHD) does not interfere with the oxygen level in the blood, but it causes abnormal blood flow patterns in the heart or blood vessels.
- There are many kinds of CCHD and ACHD, each with different symptoms, causes, and treatments. Some of the most common ones are:
- Ventricular septal defect (VSD): A hole in the wall between the lower chambers of the heart (ventricles). It is an ACHD that causes a left-to-right shunt of blood, meaning that oxygen-rich blood from the left ventricle mixes with oxygen-poor blood from the right ventricle. This can lead to increased pressure and volume in the lungs and heart failure. VSD is the most common congenital heart defect.
- Atrial septal defect (ASD): A hole in the wall between the upper chambers of the heart (atria). It is also an ACHD that causes a left-to-right shunt of blood, similar to VSD. However, ASD usually causes less symptoms and complications than VSD because the pressure in the atria is lower than in the ventricles. ASD can increase the risk of stroke, arrhythmia, and pulmonary hypertension.
- Patent ductus arteriosus (PDA): A persistent opening between the aorta and the pulmonary artery. The ductus arteriosus is a normal fetal structure that allows blood to bypass the lungs before birth. It usually closes shortly after birth, but in some cases it remains open. This is another ACHD that causes a left-to-right shunt of blood, resulting in increased workload for the heart and lungs. PDA can cause symptoms such as poor feeding, rapid breathing, and sweating.
- Tetralogy of Fallot (TOF): A combination of four heart defects: a large VSD, a narrowing of the pulmonary valve or artery (pulmonary stenosis), an enlarged right ventricle, and a displaced aorta that overrides both ventricles. It is a CCHD that causes a right-to-left shunt of blood, meaning that oxygen-poor blood from the right ventricle flows into the aorta and the rest of the body. This can cause cyanosis, especially during episodes of crying or exertion (called “tet spells”). TOF can also cause poor growth, clubbing of fingers and toes, and heart murmur.
- Transposition of the great arteries (TGA): A reversal of the positions of the aorta and the pulmonary artery. The aorta arises from the right ventricle and carries oxygen-poor blood to the body, while the pulmonary artery arises from the left ventricle and carries oxygen-rich blood to the lungs. This is a CCHD that causes severe cyanosis and breathing difficulty soon after birth. TGA requires urgent surgery to correct the blood flow.
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Type
Definition
Cause
Examples
Symptoms
Cyanotic
Heart defects that reduce the amount of oxygen in the blood, causing a bluish tint in the skin, lips, and nails
Abnormal blood flow from the right side of the heart to the left side, bypassing the lungs
Tetralogy of Fallot, transposition of the great arteries
Severe cyanosis, breathing difficulty, poor growth, clubbing of fingers and toes, heart murmur
Acyanotic
Heart defects that do not interfere with the oxygen level in the blood, but cause abnormal blood flow patterns in the heart or blood vessels
Abnormal blood flow from the left side of the heart to the right side, increasing the workload for the heart and lungs
Ventricular septal defect, atrial septal defect, patent ductus arteriosus
Mild or no cyanosis, fatigue, poor feeding, rapid breathing, sweating, heart murmur
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