Which variables can help determine the client's response to a drug? (Select all that apply.)

Liver disease

Gender

Height

Age

Genetic factors

Answer and Explanation

Correct Answer : A,C,D,E

a) Liver disease can affect drug metabolism and clearance, influencing the response to medications.

b) Gender may play a role in drug response, as there are some gender-related differences in drug metabolism and distribution.

c) Height can influence drug dosing, especially for medications with weight-based dosing.

d) Age is a crucial factor in drug response, as the metabolism and elimination of drugs can vary across different age groups.

e) Genetic factors, including variations in drug-metabolizing enzymes and drug receptors, can significantly impact an individual's response to a drug.

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Correct Answer is D

Explanation

a) Increasing the frequency of medication dosing may lead to higher overall exposure and is not necessarily related to hepatic metabolism.

b) Ordering a dose that is higher than an adult dose could result in excessive drug levels, especially in a newborn with immature hepatic function.

c) Discontinuing the drug after one or two treatments may not be necessary if the dose is appropriately adjusted based on hepatic metabolism.

d) Ordering a lower dose is appropriate because hepatic metabolism in newborns is often immature, and lower doses are required to avoid toxicity.

A. "I should monitor for Cushing's symptoms during the withdrawal process." B. "Once I am off of the steroids, I should never take them again." C. "I should not try to taper off the medication without consulting my provider." D. "I should reduce the dose by half each day until I am at 5mg, then I can stop the medication."

Correct Answer is C

Explanation

a) Monitoring for Cushing's symptoms is important, but it is not a statement indicating a good understanding of the withdrawal process from glucocorticoids.

b) Telling the client to never take steroids again is an overly generalized statement and does not reflect a nuanced understanding of the medication.

c) Not attempting to taper off the medication without consulting the provider is the correct approach. Abrupt discontinuation can lead to adrenal insufficiency, and the tapering schedule should be individualized.

d) Reducing the dose by half each day without proper guidance may result in withdrawal symptoms and is not a recommended strategy.

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Which variables can help determine the client's response to a drug? (Select all that apply.)

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A prescriber has ordered medication for a newborn that is eliminated primarily by hepatic metabolism. What would the nurse expect the prescriber to order?

Correct Answer is D

Explanation

A nurse is talking to a client who wants to stop taking glucocorticoids after taking them for 3 months. Which statement by the client indicates a good understanding of the teaching about withdrawal?

Correct Answer is C

Explanation

The nurse is scheduled to administer lispro insulin per sliding scale before meals. The serum blood glucose reading before lunch is 152 mg/dl. Given the following sliding scale, how much insulin lispro should be given before lunch? (Select the appropriate parameter.)

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