Which finding is the most common clinical manifestation of nephrotic syndrome?
Decreased skin turgor
Hypoalbuminemia
Decreased serum cholesterol
Increased serum sodium
The Correct Answer is B
Choice A reason: Decreased skin turgor is not the most common clinical manifestation of nephrotic syndrome because it is a sign of dehydration, not nephrotic syndrome. Dehydration is a condition where the body loses more fluid than it takes in, which can cause the skin to lose its elasticity and firmness. Dehydration can be caused by various factors, such as vomiting, diarrhea, fever, or excessive sweating.
Choice B reason: Hypoalbuminemia is the most common clinical manifestation of nephrotic syndrome because it is a condition where the blood has a low level of albumin, which is a protein that helps maintain the fluid balance in the body. Nephrotic syndrome is a kidney disorder that causes the kidneys to leak large amounts of protein into the urine, which reduces the amount of protein in the blood. Albumin is the most abundant protein in the blood, and it helps to keep the fluid in the blood vessels, preventing it from leaking into the tissues. When the albumin level is low, the fluid can escape from the blood vessels and cause edema, which is swelling of the body parts.
Choice C reason: Decreased serum cholesterol is not the most common clinical manifestation of nephrotic syndrome because it is a condition where the blood has a low level of cholesterol, which is a type of fat that is needed for the synthesis of hormones, bile acids, and cell membranes. Decreased serum cholesterol is not a common finding in nephrotic syndrome, because the liver tends to produce more cholesterol to compensate for the loss of protein in the urine. This can lead to hypercholesterolemia, which is a condition where the blood has a high level of cholesterol, which can increase the risk of cardiovascular diseases.
Choice D reason: Increased serum sodium is not the most common clinical manifestation of nephrotic syndrome because it is a condition where the blood has a high level of sodium, which is an electrolyte that helps regulate the fluid and acid-base balance in the body. Increased serum sodium is not a common finding in nephrotic syndrome, because the kidneys tend to excrete more sodium in the urine to balance the fluid loss caused by hypoalbuminemia. This can lead to hyponatremia, which is a condition where the blood has a low level of sodium, which can cause symptoms such as confusion, weakness, seizures, and coma.
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Correct Answer is C
Explanation
Choice A reason: Non-Hodgkin lymphoma is not the correct answer because it is a type of cancer that affects the lymphocytes, which are a type of white blood cell that are part of the immune system. Non-Hodgkin lymphoma does not have Reed-Sternberg cells, which are abnormal, large, and multinucleated cells that are characteristic of Hodgkin lymphoma.
Choice B reason: Multiple myeloma is not the correct answer because it is a type of cancer that affects the plasma cells, which are a type of lymphocyte that produce antibodies. Multiple myeloma does not have Reed-Sternberg cells, but it can have abnormal plasma cells that are called myeloma cells.
Choice C reason: Hodgkin lymphoma is the correct answer because it is a type of cancer that affects the lymphatic system, which is a network of organs, tissues, and vessels that help fight infections and diseases. Hodgkin lymphoma has Reed-Sternberg cells, which are the hallmark of this disease. Reed-Sternberg cells are thought to be derived from B lymphocytes, which are a type of lymphocyte that produce antibodies.
Choice D reason: Acute lymphocytic leukemia is not the correct answer because it is a type of cancer that affects the immature lymphocytes, which are called lymphoblasts. Acute lymphocytic leukemia does not have Reed-Sternberg cells, but it can have abnormal lymphoblasts that are called leukemic cells.
Correct Answer is B
Explanation
Choice A reason: Formation of a clot in the middle cerebral artery is not the most likely cause of death because it is a condition that affects the brain, not the heart. A clot in the middle cerebral artery can cause a stroke, which is a sudden interruption of blood flow to the brain, resulting in brain damage and neurological deficits. A stroke can be fatal, but it does not usually cause cardiopulmonary arrest, which is a sudden cessation of heart and lung function.
Choice B reason: Obstruction of left ventricular blood flow and cardiac dysrhythmias is the most likely cause of death because it is a condition that affects the heart, which is the organ responsible for pumping blood throughout the body. Obstruction of left ventricular blood flow can be caused by hypertrophic cardiomyopathy, which is a genetic disorder that causes the heart muscle to become abnormally thick and stiff, reducing the amount of blood that the heart can pump. Cardiac dysrhythmias are abnormal heart rhythms that can interfere with the electrical signals that control the heart's contractions. Both conditions can lead to sudden cardiac death, which is a sudden and unexpected loss of heart function, resulting in cardiopulmonary arrest.
Choice C reason: Fluid volume overload and decreased serum potassium levels are not the most likely cause of death because they are conditions that affect the fluid and electrolyte balance of the body, not the heart. Fluid volume overload is a condition where the body retains too much fluid, which can cause edema, hypertension, and heart failure. Decreased serum potassium levels are a condition where the blood has too little potassium, which is an electrolyte that helps regulate the nerve and muscle function, including the heart. Both conditions can affect the heart function, but they are not usually the direct cause of cardiopulmonary arrest.
Choice D reason: Diffuse atherosclerosis in the left main coronary artery circulation is not the most likely cause of death because it is a condition that affects the blood vessels, not the heart. Atherosclerosis is a disease that causes the buildup of plaque, which is a fatty substance, in the walls of the arteries, which are the blood vessels that carry oxygen-rich blood to the organs. Diffuse atherosclerosis in the left main coronary artery circulation means that the plaque affects the entire length of the artery that supplies blood to the left side of the heart, which is the side that pumps blood to the rest of the body. Atherosclerosis can cause coronary artery disease, which is a condition where the heart does not receive enough blood and oxygen, leading to chest pain, angina, or heart attack. A heart attack can cause cardiopulmonary arrest, but it is not as common as sudden cardiac death in young adults.
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