Which component forms an adhesive bridge between platelets and vascular subendothelial structures in the clotting process?

Choice A rationale:

Hemophilia is a hereditary disorder caused by a deficiency of specific clotting factors, and it is indeed hereditary in nature. This statement is incorrect.

Choice B rationale:

Hemophilia is a bleeding disorder where the blood does not clot properly. Replacement therapy, which involves infusing clotting factor concentrates, is a standard treatment for hemophilia. This statement is correct.

Choice C rationale:

Hemophilia is an X-linked recessive genetic disorder, not dominant. Males are more commonly affected because they have only one X chromosome, and if it carries the defective gene, they will have hemophilia. Females have two X chromosomes, and if one X chromosome carries the defective gene, the other X chromosome can compensate, making them carriers but not typically affected.

Choice D rationale:

Hemophilia A is the most common form of hemophilia, not hemophilia B.

Choice A rationale:

Neutropenia is a condition characterized by a low number of neutrophils, a type of white blood cell. Neutropenic patients are at increased risk of infections, but neutropenia does not cause specific changes in the tongue surface. The smooth and shiny tongue surface described in the question is not indicative of neutropenia.

Choice B rationale:

Polycythemia is a condition characterized by an abnormally high concentration of hemoglobin in the blood. It can cause the skin to appear reddish or flushed, but it does not directly cause changes in the tongue surface such as smoothness and shininess.

Choice C rationale:

Pernicious anemia is a type of anemia caused by a deficiency of vitamin B12, which is essential for the formation of red blood cells and the maintenance of the nervous system. One of the characteristic signs of pernicious anemia is glossitis, which is inflammation of the tongue that can make the tongue appear smooth and shiny. This finding aligns with the description provided in the question.

Choice D rationale:

Elevated estrogen levels can cause changes in the skin, such as increased pigmentation or the development of spider veins, but they do not directly cause changes in the tongue surface as described in the question.