The client diagnosed with vitamin B12 deficiency presents to the outpatient department for the follow-up evaluation. Which nursing assessment finding indicates that the treatment has been effective? The client:

Choice A reason: Pregnancy can increase the frequency and severity of sickle cell crises⁵⁶. Regular prenatal care is especially important for women with sickle cell disease⁵⁶. Therefore, it's crucial for a young female adult with sickle cell anemia to be aware that pregnancy increases the risk of crisis.

Choice B reason: Low oxygen levels can trigger a sickle cell crisis³. Therefore, avoiding travel to cities where the oxygen level is lower can help prevent crises.

Choice C reason: While regular, moderate exercise can be beneficial, strenuous exercise can lead to dehydration and fatigue, which can trigger a sickle cell crisis⁹[^10^]¹¹. Therefore, the statement that strenuous exercise prevents the development of sickle cell crisis is not accurate.

Choice D reason: Commercial airlines have controlled cabin pressure and oxygen levels, so flying is generally safe for individuals with sickle cell disease¹²³. However, it's always best to discuss travel plans with a healthcare provider³. Therefore, avoiding flying on commercial airlines is not necessarily a requirement.

Choice E reason: Dehydration can increase the risk of a sickle cell crisis, so it's important to drink plenty of fluids, especially in hot weather³.

Choice A reason: This is the most concerning result for the nurse. Creatinine is a waste product of muscle metabolism that is filtered by the kidneys and excreted in the urine. A high creatinine level indicates impaired kidney function, which can be a complication of hypertension. The normal range of creatinine is 0.6 to 1.2 mg/dL for men and 0.5 to 1.1 mg/dL for women. A creatinine level of 3.2 mg/dL is more than twice the upper limit of normal and suggests severe kidney damage.

Choice B reason: This is not a concerning result for the nurse. Potassium is an electrolyte that is essential for the function of nerves and muscles, especially the heart. The normal range of potassium is 3.5 to 5.0 mEq/L. A potassium level of 3.4 mEq/L is slightly below the normal range, but not enough to cause serious problems. A low potassium level can be caused by diuretics, vomiting, diarrhea, or excessive sweating. The nurse should monitor the client's potassium level and symptoms, and advise the client to eat foods that are high in potassium, such as bananas, oranges, potatoes, and tomatoes.

Choice C reason: This is not a concerning result for the nurse. Hemoglobin is a protein in the red blood cells that carries oxygen to the tissues. The normal range of hemoglobin is 13.5 to 17.5 g/dL for men and 12.0 to 15.5 g/dL for women. A hemoglobin level of 12.8 g/dL is within the normal range for women and slightly below the normal range for men, but not enough to cause significant anemia. A low hemoglobin level can be caused by blood loss, iron deficiency, or bone marrow disorders. The nurse should assess the client's history, diet, and symptoms, and check for other signs of anemia, such as pallor, fatigue, and shortness of breath.

Choice D reason: This is not a concerning result for the nurse. Blood urea nitrogen (BUN) is a waste product of protein metabolism that is filtered by the kidneys and excreted in the urine. A high BUN level indicates impaired kidney function or dehydration. The normal range of BUN is 7 to 20 mg/dL. A BUN level of 20 mg/dL is at the upper limit of normal, but not enough to indicate serious kidney problems. The nurse should ensure that the client is well hydrated and monitor the client's urine output and specific gravity.