A nurse is assessing a client who is taking an osmotic laxative. Which of the following findings should the nurse identify as an indication of fluid volume deficit?

Choice A rationale:

Fluid retention and edema are potential adverse effects of pioglitazone, a thiazolidinedione antidiabetic medication.

Choice B rationale:

Insomnia is not typically associated with pioglitazone.

Choice C rationale:

Orthostatic hypotension is not typically associated with pioglitazone.

Choice D rationale:

Tinnitus is not typically associated with pioglitazone.

Choice A rationale:

Testing negative for HIV does not mean that the client is taking the antibiotics as prescribed. HIV is a virus that weakens the immune system and makes people more susceptible to tuberculosis, but it is not related to the medication regimen for tuberculosis.

Choice B rationale:

having a positive purified protein derivative test does not mean that the client is taking the antibiotics as prescribed. A purified protein derivative test is a skin test that checks for exposure to tuberculosis bacteria, but it does not measure the effectiveness of the medication regimen. A positive test means that the client has been exposed to tuberculosis bacteria at some point in their life, but it does not mean that they have an active infection or that they are taking the antibiotics as prescribed.

Choice C rationale:

The client has a negative sputum culture. A sputum culture is a test that checks for the presence of tuberculosis bacteria in the mucus that is coughed up from the lungs. A negative sputum culture means that the bacteria are no longer detectable and that the medication regimen is effective. A positive sputum culture means that the bacteria are still present and that the medication regimen may need to be adjusted.

Choice D rationale:

Having normal liver function test results does not mean that the client is taking the antibiotics as prescribed. Liver function tests are blood tests that check for damage to the liver caused by medications or other factors. Isoniazid and rifampin can cause liver damage, so the nurse should monitor the client's liver function tests regularly to prevent or detect any problems. However, having normal liver function test results does not mean that the client is taking the antibiotics as prescribed or that the medication regimen is effective.